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Molecularly imprinted hydrophilic polymer sorbents for selective sorption of erythromycin

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Abstract

New hydrophilic polymer sorbents comprising reactionary sites which are complementary to a molecule of antibiotic erythromycin were synthesized by the method of molecular imprinting. A series of similar sorbents without reactionary sites was used for comparison of sorption characteristics. Sorption of erythromycin on both types of polymer sorbents synthesized was studied in a wide range of pH and ionic strength. Selectivity of erythromycin sorption on molecularly imprinted cross-linked polymers was shown to depend on the specific interaction of target molecule with polymer matrix. This type of sorbent is perspective for the development of antibiotic purification directly from a culture medium Saccharopolyspora erythreus.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, 199004, Russia

    N. M. Ezhova, I. S. Garkushina & O. A. Pisarev

Authors
  1. N. M. Ezhova
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  2. I. S. Garkushina
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  3. O. A. Pisarev
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Correspondence to O. A. Pisarev.

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Original Russian Text © N.M. Ezhova, I.S. Garkushina, O.A. Pisarev, 2011, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2011, Vol. 47, No. 6, pp. 694–698.

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Ezhova, N.M., Garkushina, I.S. & Pisarev, O.A. Molecularly imprinted hydrophilic polymer sorbents for selective sorption of erythromycin. Appl Biochem Microbiol 47, 635–639 (2011). https://doi.org/10.1134/S0003683811060056

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  • DOI: https://doi.org/10.1134/S0003683811060056

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