Skip to main content
Springer Nature Link
Log in

MALDI-TOF mass spectrometric identification of novel intercellular space peptides

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

We performed the matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry (MALDI-TOF) analysis of the peptides entering into the composition of not yet explored bioregulators derived from the extracellular matrix of the tissues of the various organs of the mammals, and also plants and fungi. The study included 15 different mammalian tissues, 13 species of plants, and 2 species of fungi. Exploring the bioregulators derived from eye tissues, we demonstrated that their composition includes peptide components with the same values of the molecular weight. The composition of the bioregulators derived from the tissues of various organs of mammals or different species of plants and fungi includes the peptides with different values of molecular weight. Obtained data indicate the growing evidence of the assumptions about the major function of the bioregulators of this group—their involvement in the regulation of tissue-organ homeostasis in the biological systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+
from $39.99 /Month
  • Starting from 10 chapters or articles per month
  • Access and download chapters and articles from more than 300k books and 2,500 journals
  • Cancel anytime
View plans

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  1. Yamskova, V.P., Modyanova, E.A., Levental’, V.I., Lankovskaya, T.P., Bocharova, O.K., and Malenkov, A.G., Biofizika, 1977, vol. 22, no. 1, pp. 168–174.

    CAS  Google Scholar 

  2. Malenkov, A.G., Modyanova, E.A., and Yamskova, V.P., Tsitologiya, 1978, vol. 20, no. 8, pp. 957–962.

    CAS  Google Scholar 

  3. Bueverova, E.I., Bragina, E.V., Reznikova, M.M., Yamskova, V.P., and Khrushchov, N.G., Dokl. Akad. Nauk SSSR, 1985, vol. 281, no. 1, pp. 158–160.

    PubMed  CAS  Google Scholar 

  4. Yamskova, V.P. and Reznikova, M.M., Zh. Obshch. Biol., 1991, vol. 52, no. 2, pp. 181–191.

    CAS  Google Scholar 

  5. Gundorova, R.A., Khoroshilova-Maslova, I.P., Chentsova, E.V., Ilatovskaya, L.V., Yamskova, V.P., and Romanova, I.Yu., Vopr. Oftal’mol., 1997, vol. 113, no. 2, pp. 12–15.

    CAS  Google Scholar 

  6. Yamskov, I.A., Yamskova, V.P., Danilenko, A.N., Klemenkova, Z.S., Antipov, B.G., Chernikov, F.R., Gusynina, M.M., and Rybakova, E.Yu., Ros. Khim. Zh. (Zh. Ros. Khim. Obshch. Im. D.I. Mendeleeva), 1999, vol. 43, no. 5, pp. 34–39.

    CAS  Google Scholar 

  7. Yamskova, V.P. and Yamskov, I.A., Ros. Khim. Zh. (Zh. Ros. Khim. Obshch. Im. D.I. Mendeleeva), 1999, vol. 43, no. 2, pp. 74–79.

    CAS  Google Scholar 

  8. Krasnov, M.S., Grigoryan, E.N., and Yamskova, V.P., Izv. Akad. Nauk, Ser. Biol., 2003, no. 1, pp. 22–36 [Biol. Bull. (Engl. Transl.), 2003, vol. 30, no. 1, pp. 17–29].

  9. Krasnov, M.S., Grigoryan, E.N., Yamskova, V.P., Boguslavskii, D.V., and Yamskov, I.A., Radiats. Biol. Radioekol., 2003, vol. 43, no. 3, pp. 265–268.

    CAS  Google Scholar 

  10. Margasyuk, D.V., Krasnov, M.S., Yamskova, V.P., Grigoryan, E.N., and Yamskov, I.A., Oftal’mologiya, 2005, vol. 2, no. 3, pp. 81–87.

    Google Scholar 

  11. Yamskov, I.A., Vinogradov, A.A., Danilenko, A.N., Maslova, L.A., Rybakova, E.Yu., and Yamskova, V.P., Prikl. Biokhim. Mikrobiol., 2001, vol. 37, no. 1, pp. 36–42 [Appl. Biochem. Microbiol. (Engl. Transl.), 2001, vol. 37, no. 1, pp. 29–35].

    Google Scholar 

  12. Skripnikova, V.S., Krasnov, M.S., Berezin, B.B., Babushkina, T.A., Borisenko, A.V., Izmailov, B.A., Yamskova, V.P., and Yamskov, I.A., Dokl. Akad. Nauk, 2007, vol. 417, no. 5, pp. 697–699.

    Google Scholar 

  13. Yamskov, I.A., Blagodatskikh, I.V., Krasnov, M.S., Borisenko, A.V., Margasyuk, D.V., Vecherkin, V.V., Skripnikova, V.S., Nazarova, P.A., Bitko, S.A., Berezin, B.B., Yaminskii, I.V., Meshkov, G.B., Grachev, S.A., Serebryakova, M.V., Rybakova, E.Yu., and Yamskova, V.P., Izv. Akad. Nauk, Ser. Khim., 2009, no. 3, pp. 623–628.

  14. Yamskova, V.P., Skripnikova, V.S., Molyavka, A.A., Il’ina, A.P., Krasnov, M.S., Margasyuk, D.V., Borisenko, A.V., Berezin, B.B., Kuznetsova, E.S., Buryak, A.K., and Yamskov, I.A., Biokhimiya, 2009, vol. 74, no. 9, pp. 1195–1203 [Biochemistry (Moscow), 2009, vol. 74, no. 9, pp. 971–978].

    Google Scholar 

  15. Krasnov, M.S., Margasyuk, D.V., Yamskov, I.A., and Yamskova, V.P., Radiats. Biol. Radioekol., 2003, vol. 43, no. 3, pp. 269–272.

    CAS  Google Scholar 

  16. Yamskova, V.P., Krasnov, M.S., Rybakova, E.Yu., Vecherkin, V.V., Borisenko, A.V., and Yamskov, I.A., in Biochemical Physics: Frontal Research, Varfolomeev, S.D., Burlakova, E.B., Popov, A.A., and Zaikov, G.E., Eds., Hauppauge: Nova Sci. Publ. Inc., 2007, pp. 71–78.

    Google Scholar 

  17. Borisenko, A.V., Yamskova, V.P., Krasnov, M.S., Blagodatskikh, I.V., Vecherkin, V.V., and Yamskov, I.A., in Biochemical Physics: Frontal Research, Varfolomeev, S.D., Burlakova, E.B., Popov, A.A., and Zaikov, G.E., Eds., Hauppauge: Nova Sci. Publ. Inc., 2007, pp. 35–45.

    Google Scholar 

  18. Yamskova, V.P., Modyanova, E.A., Reznikova, M.M., and Malenkov, A.G., Mol. Biol., 1977, vol. 11, no. 5, pp. 1147–1154.

    CAS  Google Scholar 

  19. Dawson, R., Elliott, D., Elliott, W., and Jones, K., Data for Biochemical Research, Oxford: Clarendon, 1986.

    Google Scholar 

  20. Borisenko, A.V., Yamskova, V.P., Blagodatskikh, I.V., Berezin, B.B., Krayukhina, M.A., and Yamskov, I.A., Biol. Membr., 2007, vol. 24, no. 3, pp. 244–250.

    CAS  Google Scholar 

  21. Margusyuk, D.V., Krasnov, M.S., Blagodatskikh, I.V., Grigoryan, E.N., Yamskova, V.P., and Yamskov, I.A., in Biochemical Physics: Frontal Research, Varfolomeev, S.D., Burlakova, E.B., Popov, A.A., and Zaikov, G.E., Eds., Hauppauge: Nova Sci. Publ. Inc., 2007, pp. 47–59.

    Google Scholar 

  22. Krasnov, M.S., Gurmizov, V.P., Yamskova, V.P., and Yamskov, I.A., in Biochemical Physics: Frontal Research, Varfolomeev, S.D., Burlakova, E.B., Popov, A.A., and Zaikov, G.E., Eds., Hauppauge: Nova Sci. Publ. Inc., 2007, pp. 21–33.

    Google Scholar 

  23. Yamskova, V.P., Krasnov, M.S., and Yamskov, I.A., Nanorazmernye bioregulyatory tkanei glaza mlekopitayushchikh kak osnova dlya farmakologicheskikh preparatov novogo pokoleniya (Nanosize Bioregulators of Mammalian Eye Tissues as a Basis for New-Generation Pharmaceuticals), Moscow: MAKS Press, 2009.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, 119991, Russia

    A. P. Il’ina, O. G. Kulikova, D. I. Maltsev & I. A. Yamskov

  2. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    M. S. Krasnov, E. Yu. Rybakova, V. S. Skripnikova & V. P. Yamskova

  3. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, 119991, Russia

    E. S. Kuznetsova & A. K. Buryak

Authors
  1. A. P. Il’ina
    View author publications

    Search author on:PubMed Google Scholar

  2. O. G. Kulikova
    View author publications

    Search author on:PubMed Google Scholar

  3. D. I. Maltsev
    View author publications

    Search author on:PubMed Google Scholar

  4. M. S. Krasnov
    View author publications

    Search author on:PubMed Google Scholar

  5. E. Yu. Rybakova
    View author publications

    Search author on:PubMed Google Scholar

  6. V. S. Skripnikova
    View author publications

    Search author on:PubMed Google Scholar

  7. E. S. Kuznetsova
    View author publications

    Search author on:PubMed Google Scholar

  8. A. K. Buryak
    View author publications

    Search author on:PubMed Google Scholar

  9. V. P. Yamskova
    View author publications

    Search author on:PubMed Google Scholar

  10. I. A. Yamskov
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to A. K. Buryak.

Additional information

Original Russian Text © A.P. Il’ina, O.G. Kulikova, D.I. Maltsev, M.S. Krasnov, E.Yu. Rybakova, V.S. Skripnikova, E.S. Kuznetsova, A.K. Buryak, V.P. Yamskova, I.A. Yamskov, 2011, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2011, Vol. 47, No. 2, pp. 135–140.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Il’ina, A.P., Kulikova, O.G., Maltsev, D.I. et al. MALDI-TOF mass spectrometric identification of novel intercellular space peptides. Appl Biochem Microbiol 47, 118–122 (2011). https://doi.org/10.1134/S0003683811020049

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0003683811020049

Keywords