Skip to main content

Sulfated polysaccharides and their anticoagulant activity: A review

Applied Biochemistry and Microbiology volume 46, pages 267–273 (2010)Cite this article

Abstract

Published data on the sulfated polysaccharides of various origins that display an anticoagulant activity are summarized and analyzed. The methods used for producing semisynthetic derivatives are considered. A key role of the polysaccharide structure in the mechanisms of specific interaction with various blood plasma proteinases is discussed. The effects of the content and location of sulfate groups in polysaccharides and their molecular weight on the degree of the studied activity are assessed.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price includes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. Toida, T., Chaidedgumjorn, A., and Linhard, R.J., Trends Glycosc. Glycotechnol., 2003, vol. 15, no. 81, pp. 29–46.

    CAS  Google Scholar 

  2. Drozd, N.N., Bannikova, G.E., Makarov, V.A., and Varlamov, V.P., Eksp. Klin. Farmakol., 2006, vol. 69, no. 6, pp. 51–60.

    CAS  PubMed  Google Scholar 

  3. Maruyama, T., Toida, T., Imanari, G.Yu., and Linhardt, R.J., Carbohydr. Res., 1998, vol. 306, no. 1, p. 35–43.

    Article  CAS  PubMed  Google Scholar 

  4. Pacheco, R.G., Vicente, C.P., Zancan, P., and Mourao, P.A., Blood Coagul. Fibrinolysis, 2000, vol. 11, no. 6, pp. 563–573.

    Article  CAS  PubMed  Google Scholar 

  5. Yoon, S.J., Pyun, Y.R., Hwang, J.K., and Mourao, P.A., Carbohydr. Res., 2007, vol. 342, no. 15, pp. 2326–2330.

    Article  CAS  PubMed  Google Scholar 

  6. Cumashi, A., Ushakova, N.A., Preobrazhenskaya, M.E., D’Incecco, A., Piccoli, A., Totani, L., Tinar, N., Morozevich, G.E., Berman, A.E., Bilan, M.I., Usov, A.I., Ustyuzhanina, N.E., Grachev, A.A., Sanderson, C.J., Kelly, M., Rabinovich, G.A., Iacobelli, S., and Nifantiev, N.E., Glycobiology, 2007, vol. 17, no. 5, pp. 541–552.

    Article  CAS  PubMed  Google Scholar 

  7. Cardoso, MA., Noseda, MD., Fujii, MT., Zibetti, RG.M., and Duarte, M.E.R., Carbohydr. Res., 2007, vol. 342, no. 18, pp. 2766–2775.

    Article  CAS  PubMed  Google Scholar 

  8. Zhao, X., Yu, G., Guan, H., Yue, N., Zang, Z., and Li, H., Carbohydr. Res., 2007, vol. 62, no. 3, pp. 272–279.

    Google Scholar 

  9. Lin, C.Z., Guan, H.S., Li, H.H., Yu, G.L., Gu, C.H., and Li, G.Q., Eur. Polymer J., 2007, vol. 43, no. 7, pp. 3009–3015.

    Article  CAS  Google Scholar 

  10. Jayakumar, R., Nwe, N., Tokura, S., and Tamura, H., Int. J. Biol. Macromol., 2007, vol. 40, no. 1, pp. 175–181.

    Article  CAS  PubMed  Google Scholar 

  11. Zou, Y. and Khor, E., Carbohydr. Polymers, 2009, vol. 77, no. 3, pp. 516–525.

    Article  CAS  Google Scholar 

  12. Geresh, S., Mamontov, A., and Weinstein, J., J. Biochem. Biophis. Methods, 2002, vol. 50, no. 1, pp. 179–187.

    Article  CAS  Google Scholar 

  13. Alban, S., Kraus, J., and Franz, G., Arzneimittelforschung, 1992, vol. 42, no. 8, pp. 1005–1008.

    CAS  PubMed  Google Scholar 

  14. Martinichen-Herrero, J.C., Carbonero, E.R., Sassaki, G.L., Gorin, P.A., and Iacomini, M., Int. J. Biol. Macromol., 2005, vol. 35, nos. 1–2, pp. 97–102.

    Article  CAS  PubMed  Google Scholar 

  15. Wang, Z.M., Li, L., Zheng, B.S., Normakhamatov, N., and Guo, S.Y., Int. J. Biol. Macromol., 2007, vol. 41, no. 2, p. 376.

  16. Dace, R., McBride, E., Brooks, K., Gander, J., Buszko, M., and Doctor, V., M, Thrombosis Res., 1997, vol. 87, no. 1, pp. 112–121.

    Article  Google Scholar 

  17. Zhang, Y., Xie, B., and Gan, X., Carbohydr. Polym., 2005, vol. 60, no. 1, pp. 27–31.

    Article  CAS  Google Scholar 

  18. Pires, L., Gorin, P.A., Reicher, F., and Sierakowski, M.-R., Carbohydr. Res., 2001, vol. 46, no. 1, pp. 165–169.

    CAS  Google Scholar 

  19. Ono, L., Wollinger, W., Rocco, I.M., Gorin, P.A., and Sierakowski, M.-R., Antiviral Res., 2003, vol. 60, no. 3, pp. 201–208.

    Article  CAS  PubMed  Google Scholar 

  20. Mestechkina, N.M., Shcherbukhin, V.D., Bannikova, G.E., Varlamov, V.P., Drozd, N.N., Tolstenkov, A.S., Makarov, V.A., and Tikhonov, V.E., Appl. Biochim. Microbiol., 2008, vol. 44, no. 1, pp. 98–103.

    CAS  Google Scholar 

  21. Huynh, R., Chaubet, F., and Jozefovicz, J., Carbohydr. Res., 2001, vol. 332, no. 1, pp. 75–83.

    Article  CAS  PubMed  Google Scholar 

  22. Mihai, D., Mocanu, G., and Carpov, A., Eur. Polym. J., 2001, vol. 37, no. 3, pp. 541–546.

    Article  CAS  Google Scholar 

  23. Alban, S. and Franz, G., Thrombosis Res., 2000, vol. 99, no. 2, pp. 377–388.

    Article  CAS  Google Scholar 

  24. Yang, J., Du, Y., Wen, Y., Li, T., and Hu, L., Carbohydr. Res., 2003, vol. 52, no. 4, pp. 397–403.

    Article  CAS  Google Scholar 

  25. Mestechkina, N.M., Egorov, A.V., and Shcherbukhin, V.D., Applied Biochem. Microbiol., 2006, vol. 42, no. 3, pp. 368–373.

    CAS  Google Scholar 

  26. Chaidedgumjorn, A., Toyoda, H., Woo, E.R., Lee, K.B., Kim, Y.S., Toida, T., and Imanaria, T., Carbohydr. Res., 2002, vol. 337, no. 10, pp. 925–933.

    Article  CAS  PubMed  Google Scholar 

  27. Burgermeister, J., Paper, D.H., Vogl, H., Linhardt, R.J., and Franz, G., Carbohydr. Res., 2002, vol. 337, no. 16, pp. 1459–1466.

    Article  CAS  PubMed  Google Scholar 

  28. Vikhoreva, G., Bannikova, G., Stolbushkina, P., Panov, A., Drozd, N., Makarov, V., Varlamov, V., and Gal’braikh, L., Carbohydr. Res., 2005, vol. 62, no. 4, pp. 327–332.

    Article  CAS  Google Scholar 

  29. Bao, X., Duan, J., Fang, X., and Fang, J., Carbohydr. Res., 2001, vol. 336, no. 1, pp. 127–140.

    Article  CAS  PubMed  Google Scholar 

  30. Mestechkina, N.M., Shcherbukhin, V.D., and Shashkov, A.S., Russ. Chem. Bull., 2008, vol. 57, no. 8, pp. 1779–1783.

    Article  CAS  Google Scholar 

  31. Chen, F.T., Shen, G., and Evangelista, R.A., J. Chromatogr., A, 2001, vol. 924, nos. 1-2, pp. 523–532.

    Article  CAS  Google Scholar 

  32. Yang, J., Huang, R., Wan, Y., and Wen, Y., Int. J. Biol. Macromol., 2005, vol. 36, nos. 1–2, pp. 9–15.

    Article  CAS  PubMed  Google Scholar 

  33. Mahner, G., Lechner, M.D., and Nordmeier, E., Carbohydr. Res., 2001, vol. 331, no. 2, pp. 203–208.

    Article  CAS  PubMed  Google Scholar 

  34. Pereira, M.S., Vilela-Silva, A.-C.E.S., Valente, A.-P., and Mourao, P.A.S., Carbohydr. Res., 2002, vol. 337, nos. 21-23, pp. 2231–2238.

    Article  CAS  PubMed  Google Scholar 

  35. Nishino, T. and Nagumo, T., Carbohydr. Res., 1992, vol. 229, no. 2, pp. 355–362.

    Article  CAS  PubMed  Google Scholar 

  36. Haroun-Bouhedja, F., Ellouali, M., Sinquin, C., and Boisson-Vidal, C., Thrombosis. Res., 2000, vol. 100, no. 5, pp. 453–459.

    Article  CAS  Google Scholar 

  37. Lee, K.B., Bae, J.H., Kim, J.S., Yoo, Y.C., Kim, B.S., and Kwak, S.T., Arch. Pharm. Res., 2001, vol. 24, no. 2, pp. 109–113.

    Article  CAS  PubMed  Google Scholar 

  38. Groth, T. and Wagenknecht, W., Biomaterials, 2001, vol. 22, no. 20, pp. 2719–2729.

    Article  CAS  PubMed  Google Scholar 

  39. Martinichen-Herrero, J.C., Carbonero, E.R., Gorin, P.A.J., and Iacomini, M., Carbohydr. Res., 2005, vol. 60, no. 1, pp. 7–13.

    Article  CAS  Google Scholar 

  40. Qiu, X., Amarasekara, A., and Doctor, V., Carbohydr. Res., 2006, vol. 63, no. 2, pp. 224–228.

    Article  CAS  Google Scholar 

  41. Maaroufi, R.M., Giordano, P., Triadou, P., Tapon-Bretaudiere, J., Dautzenberg, M.D., and Fischer, A.M., Thrombosis Res., 2007, vol. 120, no. 4, pp. 615–621.

    Article  CAS  Google Scholar 

  42. Alban, S. and Franz, G., Pure Appl. Chem., 1994, vol. 66, no. 10, pp. 2403–2406.

    Article  CAS  Google Scholar 

  43. Melo, F.R., Pereira, M.S., Foguel, D., and Mourao, P.A., J. Biol. Chem., 2004, vol. 279, no. 20, pp. 20824–20835.

    Article  CAS  PubMed  Google Scholar 

  44. Pomin, V.H., Pereira, M.S., Valente, A.-P., Tollefsen, D.M., Pavao, M.S.G., and Mourao, P.A.S., Glycobiology, 2005, vol. 15, no. 4, pp. 369–381.

    Article  CAS  PubMed  Google Scholar 

  45. Zhang, H.J., Mao, W.J., Fang, F., Li, H.Y., Sun, H.H., Chen, Y., and Qi, X.H., Carbohydr. Polym., 2008, vol. 71, no. 3, pp. 428–434.

    Article  CAS  Google Scholar 

  46. Barbucci, R., Lamponi, S., Magnani, A., and Renier, D., Biamaterials, 1998, vol. 19, nos. 7–9, pp. 801–809.

    Article  CAS  Google Scholar 

  47. Franz, G. and Alban, S., Int. J. Macromol., 1995, vol. 17, no. 6, pp. 311–314.

    Article  CAS  Google Scholar 

  48. Chevolot, L., Foucault, A., Chaubet, F., Kervarec, N., Sinquin, C., and Fisher, A. M., Carbohydr. Res., 1999, vol. 319, no. 1, pp. 154–165.

    Article  CAS  PubMed  Google Scholar 

  49. Pereira, M.S., Melo, F.R., and Mourao, P.A.S., Clycobiology, 2002, vol. 12, no. 10, pp. 573–580.

    Article  CAS  Google Scholar 

  50. Mulloy, B., Mourao, P.A.S., and Gray, E., J. Biotechnol., 2000, vol. 77, no. 1, pp. 123–135.

    Article  CAS  PubMed  Google Scholar 

  51. Vicente, C.R., Zancan, H., Peixoto, L.L., Alves-Sa, R., Araujo, F.S., Mourao, P.A., and Pavao, M.S., Tromb. Haemost., 2001, vol. 86, no. 5, pp. 1215–1220.

    CAS  Google Scholar 

  52. Nader, H.B., Lopes, C.C., Rocha, H.A., Santos, E.A., and Dietrich, C.P., Curr. Pharm. Des., 2004, vol. 10, no. 9, pp. 951–966.

    Article  CAS  PubMed  Google Scholar 

  53. Becker, C.F., Guimaraes, J.A., Mourao, P.A.S., and Verli, H., J. Mol. Graph. Model., 2007, vol. 26, no. 1, pp. 391–399.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia

    N. M. Mestechkina & V. D. Shcherbukhin

Authors
  1. N. M. Mestechkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. D. Shcherbukhin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. D. Shcherbukhin.

Additional information

Original Russian Text © N.M. Mestechkina, V.D. Shcherbukhin, 2010, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2010, Vol. 46, No. 3, pp. 291–298.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mestechkina, N.M., Shcherbukhin, V.D. Sulfated polysaccharides and their anticoagulant activity: A review. Appl Biochem Microbiol 46, 267–273 (2010). https://doi.org/10.1134/S000368381003004X

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S000368381003004X

Keywords

  • Polysaccharide
  • Apply Biochemistry
  • Sulfation
  • Anticoagulant Activity
  • Dermatan Sulfate