Advances in Gerontology

, Volume 8, Issue 4, pp 320–327 | Cite as

Histometric Symptoms of Age-Sensitive Changes of Bone Tissue

  • Y. I. Pigolkin
  • G. V. ZolotenkovaEmail author
  • A. P. Sereda
  • D. D. Zolotenkov
  • N. V. Gridina


This study presents the results of complex histomorphometric research of the features of age-related dynamics of bone tissue. We used as study material samples of the distal epiphysis and diaphysis of the left tibia from 348 male corpses aging from 0 to 90 years. The group of microosteometric features that have the strongest correlation with age is established in different age groups; their quantitative characteristics are given here. It has been clarified that the trends of age-related changes in the structural components of bone tissue correspond to the basic patterns of growth, remodeling, and depend on the species and their localization. Conceptual positions of age involution of bone tissue are proposed in this study.


histomorphometry age-related changes bone tissue morphology 



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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Y. I. Pigolkin
    • 1
  • G. V. Zolotenkova
    • 2
    Email author
  • A. P. Sereda
    • 3
  • D. D. Zolotenkov
    • 1
  • N. V. Gridina
    • 1
    • 4
  1. 1.Sechenov the First State Medical UniversityMoscowRussia
  2. 2.Bureau of Forensic Medical Examination of the Moscow oblastMoscowRussia
  3. 3.Federal Biomedical Agency of RussiaMoscowRussia
  4. 4.Center of Information Technologies in Design RASMoscow oblastRussia

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