Advances in Gerontology

, Volume 6, Issue 4, pp 328–332 | Cite as

The effect of vascular peptide bioregulator on microcirculation in the brain cortex of old rats

  • I. B. Sokolova
  • I. V. Sergeev
  • G. A. Ryzhak
  • V. Kh. Khavinson


At a video facility for the study of intravital brain microcirculation, we found that, after a course treatment with vascular peptide bioregulator, the microvasculature density of the pial tunic in old (22–24 months) rats increased by about 2.5–2.8 times; the constriction and dilative reactions of the pial arterioles increased after the application of noradrenaline and acetylcholine onto the brain surface, respectively. However, perfusion into brain tissues did not increase, but the degree of oxygen saturation in microvessels of this tissue region increased.


vascular peptide bioregulator old animals density of microvascular network arterial reactivity brain 


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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • I. B. Sokolova
    • 1
  • I. V. Sergeev
    • 1
  • G. A. Ryzhak
    • 2
  • V. Kh. Khavinson
    • 1
    • 2
  1. 1.Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia
  2. 2.St. Petersburg Institute of Bioregulation and GerontologySt. PetersburgRussia

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