Advances in Gerontology

, Volume 5, Issue 4, pp 219–224 | Cite as

Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation in aging

  • V. Kh. Khavinson
  • S. I. Tarnovskaya
  • N. S. Linkova
  • E. O. Gutop
  • E. V. Elashkina


Short peptides, vesugen and D-7, stimulated the synthesis of the proliferation-associated protein Ki-67, the expression of which decreased during aging in tissue-specific cell cultures obtained from young and old animals and in dissociated vascular endothelial cell cultures. Molecular docking methods were used to reveal the possibility of binding the vesugen and D-7 peptides to the promoter regions of the MKI67 gene, which encodes the Ki-67 protein. Both peptides have contact through the CATC sequence with core promoter 5'-agcctcaaccatcaggaaaacaagagt-3', which is located in the MKI67 gene (ENSG00000148773) from -14 to +12 bp relative to the transcriptional initiation site. Thus, the vasoprotective effect of vesugen, which was previously revealed in elder people, can be manifested through epigenetic regulation of the Ki-67 gene expression.


epigenetics peptides proliferation vascular endothelium aging molecular modeling 


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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • V. Kh. Khavinson
    • 1
    • 2
  • S. I. Tarnovskaya
    • 2
  • N. S. Linkova
    • 2
  • E. O. Gutop
    • 2
  • E. V. Elashkina
    • 2
  1. 1.Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia
  2. 2.St. Petersburg Institute of Bioregulation and GerontologySt. PetersburgRussia

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