Short peptides stimulate cell regeneration in skin during aging
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The search for new safe and efficient low-molecular weight substances stimulating skin regeneration is an important objective of geriatric cosmetology. The present study addressed the effects of the peptides LK and AEDG at concentrations of 0.05–2.00 ng/mL on the proliferation of organotypic tissue cultures of skin from young and old animals. The application of peptides enhanced fibroblast proliferation in skin cell cultures from young and old animals by 29–45%. The effect on aging skin was observed in a narrower concentration range; in addition, it was less pronounced than the effect on skin cell cultures obtained from young animals. These data reveal the potential of LK and AEDG as components of cosmetic products that restore the structure of aging skin.
Keywordsshort peptides cell proliferation organotypic culture skin aging
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- 2.Khavinson, V.Kh., Korol’ko, T.N., and Ryzhak, G.A., Prospective implementation of peptide bioregulators in gerontological cosmetology, Vestn. Dermatol. Venerol. 2005, no. 4, pp. 56–59Google Scholar
- 5.Chalisova, N.I., Koncevaya, E.A., Linkova, N.S., et al., Biological activity of amino acids in organotypic tissue cultures, Cell Technol. Biol. Med. 2013, no. 2, pp. 581–585Google Scholar
- 6.Fedoreeva, L.I., Kireev, I.I., Khavinson, V.Kh., and Vanyushin, B.F., Penetration of short fluorescence labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA, Biochemistry 2010, vol. 76, pp. 1210–1219Google Scholar
- 12.Lorencini, M., Brohem, C.A., Dieamant, G.C., et al., Active ingredients against human epidermal aging, Ageing Res Rev. 2014, pp. S1568–1637Google Scholar
- 13.Makpol, S., Abdul Rahim, N., Hui, C.K., and Ngah, W.Z., Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts, Oxid. Med. Cell. Longevity 2012, pp. 1345–1349Google Scholar
- 15.Suschek, C.V., Schnirr, O., and Hemmrich, K., Critical role of L-arginine in endothelial cell survival during oxidative stress, Circulation 2003, vol. 107, pp. 2007–2014.Google Scholar