Age-related molecular aspects of immunomodulating activity of peptides in the spleen
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In this work, it was shown that short peptides, such as vilon, thymogen, crystagen and R-1, possess different age-associated immunoprotecting properties in the spleen. Both the R-1 and vilon peptides were found to activate T-helper cells. T-Helper activation by vilon was based on the inhibition of cellular apoptosis, whereas R-1 acted through positive stimulation of cellular proliferation and differentiation. Thymogen was found to be an activator of B-lymphocytes and acted through the inhibition of apoptosis, as well as by the stimulation of spleen cells proliferation. Crystagen was also found to activate the B-cell immunity system but had no effect on the processes of cellular renewal in the spleen during aging.
Keywordsimmune cells peptides spleen aging
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