Advances in Gerontology

, Volume 4, Issue 1, pp 12–15 | Cite as

Age-related molecular aspects of immunomodulating activity of peptides in the spleen

  • N. A. Chervyakova
  • N. S. Lin’kova
  • N. I. Chalisova
  • E. A. Kontsevaya
  • S. V. Trofimova
  • V. Kh. Khavinson
Article
  • 22 Downloads

Abstract

In this work, it was shown that short peptides, such as vilon, thymogen, crystagen and R-1, possess different age-associated immunoprotecting properties in the spleen. Both the R-1 and vilon peptides were found to activate T-helper cells. T-Helper activation by vilon was based on the inhibition of cellular apoptosis, whereas R-1 acted through positive stimulation of cellular proliferation and differentiation. Thymogen was found to be an activator of B-lymphocytes and acted through the inhibition of apoptosis, as well as by the stimulation of spleen cells proliferation. Crystagen was also found to activate the B-cell immunity system but had no effect on the processes of cellular renewal in the spleen during aging.

Keywords

immune cells peptides spleen aging 

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • N. A. Chervyakova
    • 1
  • N. S. Lin’kova
    • 1
  • N. I. Chalisova
    • 2
  • E. A. Kontsevaya
    • 1
  • S. V. Trofimova
    • 1
  • V. Kh. Khavinson
    • 1
    • 2
  1. 1.Saint-Petersburg Institute of Bioregulation and GerontologySt. PetersburgRussia
  2. 2.Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia

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