Age-related changes in number of CD45-positive cells in human dermis
- 90 Downloads
Age-related changes in the number of leucocytes and other cells of bone marrow origin were investigated in human dermis. The total number of CD45-positive cells increased with age, while the amount of fibroblasts in the dermis gradually decreased. Additionally, an age-related decrease in the number of PCNA-positive fibroblast-like cells, which indicates their proliferative activity, was clearly shown. The correlation analysis revealed that the age-associated increase in the amount of CD45-positive cells is statistically related to a decrease in the total number of PCNA-positive fibroblast-like cells in the dermis. Therefore, the accumulation of CD45-positive cells in the human dermis with age may well be regarded as a mechanism that initiates an inflammatory response and is responsible for the emergence of signs of aging. It is also possible that an increased number of bone marrow-derived cells in the dermis, which are accumulated with age, has an effect on the age-related decrease in the amount of fibroblasts in the dermis.
Keywordsskin aging CD45 fibroblasts proliferation PCNA
Unable to display preview. Download preview PDF.
- 2.Dall’olio, F., Vanhooren, V., Chen, C.C., et al., N-glycomic biomarkers of biological aging and longevity: a link with inflamm-aging, Aging Res. Rev., 2012. doi: 10.1016/j.arr.2012.02.002Google Scholar
- 7.Hwang, K.A., Yi, B.R., and Choi, K.C., Molecular mechanisms and in vivo mouse models of skin aging associated with dermal matrix alterations, ILAR J., 2011, vol. 27, pp. 1–8.Google Scholar
- 20.Wang, B., Photoaging: a review of current concepts of pathogenesis, J. Cutaneous Med. Surg., 2011, vol. 15, pp. S374–S377.Google Scholar
- 21.Wang, Y., Sun, Y., Yang, X.Y., et al., Mobilized bone marrow-derived cells accelerate wound healing, Int. Wound. J., 2012. doi: 10.1111/j.1742-481X.2012.01007.xGoogle Scholar