Age-related changes in number of CD45-positive cells in human dermis
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Age-related changes in the number of leucocytes and other cells of bone marrow origin were investigated in human dermis. The total number of CD45-positive cells increased with age, while the amount of fibroblasts in the dermis gradually decreased. Additionally, an age-related decrease in the number of PCNA-positive fibroblast-like cells, which indicates their proliferative activity, was clearly shown. The correlation analysis revealed that the age-associated increase in the amount of CD45-positive cells is statistically related to a decrease in the total number of PCNA-positive fibroblast-like cells in the dermis. Therefore, the accumulation of CD45-positive cells in the human dermis with age may well be regarded as a mechanism that initiates an inflammatory response and is responsible for the emergence of signs of aging. It is also possible that an increased number of bone marrow-derived cells in the dermis, which are accumulated with age, has an effect on the age-related decrease in the amount of fibroblasts in the dermis.
Keywordsskin aging CD45 fibroblasts proliferation PCNA
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