Advances in Gerontology

, Volume 2, Issue 2, pp 109–119 | Cite as

The issue of the feasibility of a general theory of aging. III. Theory and practice of aging

Article

Abstract

Analysis of demographic data on human mortality and lifespan carried out according to the complete Gompertz-Makeham model μ = C + λeγxt shows that, over the last 100 years, the life expectancy increased almost exclusively because the Makeham parameter C decreased. The observed changes in the demographic aging rate γ and in the initial vitality, which is inversely proportional to lnλ, may be largely an artifact of the attempts to decompose mortality data related to conditions that significantly change within a time scale comparable to the human lifespan, whereas the correct decomposition of mortality change by different Gompertz-Makeham parameters is possible only for a strictly homogeneous population under strictly stationary conditions. What actually remains of changes in these parameters, while theoretically significant, would probably be negligible in the quantitative practical aspect. The comparison of this situation with experiments on animals, suggesting possible interferences that may decrease the aging rate and/or increase the lifespan, reveals that the main factors of reduced mortality and, correspondingly, increased lifespan in human beings are limited to one’s personal commitment to following long-standing and readily available guidelines for healthy life, which may help bring one’s lifespan about 10 years closer to the reliably recorded maximum of 122 years, although they obviously do not guarantee it. The bottleneck for the realization of this reserve resides in public and individual mentality rather than in science.

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References

  1. 1.
    Anisimov, V.N., Means of Prevention of Premature Aging (Geroprotectors), Usp. Gerontol., 2000, no. 4, pp. 55–73.Google Scholar
  2. 2.
    Golubev, A.G., Catecholamines, Steroids, and Aging of the Nervous and Endocrinal Systems, Usp. Sovrem. Biol., 1989, no. 6, pp. 64–75.Google Scholar
  3. 3.
    Golubev, A.G., Alzheimer’s Disease, Amiloidoses, and Aging, Usp. Gerontol., 2000, no. 4, pp. 102–112.Google Scholar
  4. 4.
    Golubev, A.G., Biochemistry of Life Prolongation, Usp. Gerontol., 2003, no. 12, pp. 57–76.Google Scholar
  5. 5.
    Golubev, A. How Could the Gompertz-Makeham Law Evolve? J. Theor. Biol., 2009, vol. 258, pp. 1–17.PubMedCrossRefGoogle Scholar
  6. 6.
    Golubev, A.G., The Issue of Feasibility of a General Theory of Aging: II. Parametabolic Theory of Aging, Usp. Gerontol., 2009, no. 2, pp. 205–222.Google Scholar
  7. 7.
    Alley, D., Suthers, K., and Crimmins, E., Education and Cognitive Decline in Older Americans: Results from the AHEAD Sample, Res. Aging, 2007, vol. 29, pp. 73–94.PubMedCrossRefGoogle Scholar
  8. 8.
    Allison, D.B., Miller, R.A., Austad, S.N., et al., et al., Genetic Variability in Responses to Caloric Restriction in Animals and in Regulation of Metabolism and Obesity in Humans, J. Geront. Ser. A, 2001, vol. 56A, pp. 55–65.CrossRefGoogle Scholar
  9. 9.
    Ang, L.S., Cruz, R.P., Hendel, A., and Granville, D.J., Apolipoprotein E, an Important Player in Longevity and Age-Related Diseases, Exp. Gerontol., 2008.Google Scholar
  10. 10.
    Bjelakovic, G., Nikolova, D., Gluud, L.L., et al., et al., Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-Analysis, J.A.M.A., 2007, vol. 297, pp. 842–857.PubMedCrossRefGoogle Scholar
  11. 11.
    de Gray, A.D., The Foreseeability of Real Antiaging Medicine: Focusing the Debate, Exp. Gerontol., 2003, vol. 38, pp. 927–934.CrossRefGoogle Scholar
  12. 12.
    de la Fuente-Fernandez, R., Impact of Neuroprotection on Incidence of Alzheimer’s Disease, PLoS ONE, 2006, vol. e52. doi: 10.1371/journal.pone.0000052.Google Scholar
  13. 13.
    Deary, I., Why Do Intelligent People Live Longer?, Nature, 2008, vol. 456, pp. 175–176.PubMedCrossRefGoogle Scholar
  14. 14.
    Feinleib, M., Epidemiology of Obesity in Relation to Health Hazards, Ann. Int. Med., 1985, vol. 103, pp. 1019–1024.PubMedGoogle Scholar
  15. 15.
    Fraser, G.E. and Shavlik, D.J., Ten Years of Life: Is It a Matter of Choice?, Arch. Int. Med., 2001, vol. 161, pp. 1645–1652.CrossRefGoogle Scholar
  16. 16.
    Hanson, R.W. and Hakimi, P., Born to Run: The Story of the PEPCK-Cmus Mouse, Biochimie, 2008, vol. 90, pp. 838–842.PubMedCrossRefGoogle Scholar
  17. 17.
    Harris, B., Growing Taller, Living Longer? Anthropometric History and the Future of Old Age, Aging and Society, 1997, vol. 17, pp. 491–512.CrossRefGoogle Scholar
  18. 18.
    Holliday, R., Human Ageing and the Origins of Religion, Biogerontology, 2001, vol. 2, pp. 73–77.PubMedCrossRefGoogle Scholar
  19. 19.
    Holloszy, J.O., Longevity of Exercising Male Rats: Effect of an Antioxidant Supplemented Diet, Mech. Aging Dev., 1998, vol. 100, pp. 211–219.PubMedCrossRefGoogle Scholar
  20. 20.
    Holloszy, J.O. and Fontana, L., Caloric Restriction in Humans, Exp. Gerontol., 2007, vol. 42, pp. 709–712.PubMedCrossRefGoogle Scholar
  21. 21.
    Hotamisligil, G.S., Inflammation and Metabolic Disorders, Nature, 2006, vol. 444, pp. 860–867.PubMedCrossRefGoogle Scholar
  22. 22.
    Huang, H.Y., Helzlsouer, K.J., and Appel, L.J., The Effects of Vitamin C and Vitamin E on Oxidative DNA Damage: Results from a Randomized Controlled Trial, Cancer Epidem. Biomarkers Prev., 2000, vol. 9, pp. 647–652.Google Scholar
  23. 23.
    Khazaeli, A.A., Van Voorhies, W., and Curtsinger, J.W., The Relationship between Life Span and Adult Body Size Is Highly Strain-Specific in Drosophila melanogaster, Exp. Geront., 2005, vol. 40, pp. 377–385.CrossRefGoogle Scholar
  24. 24.
    Kopp, M.S., Skrabski, A.D., Szekely, A., et al., et al., Socioeconomic Determination of Chronic Stress, Ann. N.Y. Acad. Sci, 2007, vol. 1113, pp. 325–338.PubMedCrossRefGoogle Scholar
  25. 25.
    la Cour, P., Avlund, K., and Schultz-Larsen, K., Religion and Survival in a Secular Group: A Twenty Year Follow-up of 734 Danish Adults Born in 1914, Soc. Sci. Med., 2006, vol. 62, pp. 167–164.Google Scholar
  26. 26.
    Lange-Asschenfeldt, C. and Kojda, G., Alzheimer’s Disease, Cerebrovascular Dysfunction and the Benefits of Exercise: From Vessels to Neurons, Exp. Geront., 2008, vol. 43, pp. 499–504.CrossRefGoogle Scholar
  27. 27.
    Markham, J.A. and Greenough, W.T., Experience-Driven Brain Plasticity: Beyond the Synapse, Neuron Glia Biol., 2004, vol. 1, pp. 351–363.PubMedCrossRefGoogle Scholar
  28. 28.
    Marmot, M.G., Alcohol and Coronary Heart Disease, Int. J. Epidem., 2001, vol. 30, pp. 724–729.CrossRefGoogle Scholar
  29. 29.
    McTiernan, A., Ulrich, C., Slate, S., and Potter, J., Physical Activity and Cancer Etiology: Associations and Mechanisms, Cancer Causes Control, 1998, vol. 9, pp. 487–509.PubMedCrossRefGoogle Scholar
  30. 30.
    Mehlman, M.J., Binstock, R.H., Juengst, E.T., et al.,et al., Anti-Aging Medicine: Can Consumers Be Better Protected?, The Gerontologist, 2004, vol. 44, pp. 304–310.PubMedCrossRefGoogle Scholar
  31. 31.
    Oeppen, J., Life Expectancy Convergence Among Nations since 1820: Separating the Effects of Technology and Income, Perspectives on Mortality Forecasting. III. The Linear Rise in Life Expectancy: History and Prospects, Social Insurance Studies, Bengtsson, T., Ed., Swedish Social Insurance Agency, 2006, no. 3., pp. 55–83.Google Scholar
  32. 32.
    Paffenbarger, R.S., Hyde, R.T., Wing, A.L., et al., The Association of Changes in Physical-Activity Level and Other Lifestyle Characteristics with Mortality among Men, N. Engl. J. Med., 1993, vol. 328, pp. 538–545.PubMedCrossRefGoogle Scholar
  33. 33.
    Pedersen, J.Ø., Heitmann B. L., Schnohr P, Grønbøk M., The Combined Influence of Leisure-Time Physical Activity and Weekly Alcohol Intake on Fatal Ischaemic Heart Disease and All-Cause Mortality, Eur. Heart J., 2008, vol. 29, pp. 1–9.CrossRefGoogle Scholar
  34. 34.
    Phelan, J.P. and Rose, M.R., Why Dietary Restriction Substantially Increases Longevity in Animal Models but Won’t in Humans, Aging Res. Rev., 2005, vol. 4, pp. 339–350.CrossRefGoogle Scholar
  35. 35.
    Prencipe, M., Casini, A.R., Ferretti, C., et al.,et al., Prevalence of Dementia in an Elderly Rural Population: Effects of Age, Sex, and Education, J. Neurol. Neurosurg. Psychiat., 1996, vol. 60, pp. 628–633.PubMedCrossRefGoogle Scholar
  36. 36.
    Riley, K.P., Snowdon, D.A., Desrosiers, M.F., and Markesbery, W.R., Early Life Linguistic Ability, Late Life Cognitive Function, and Neuropathology: Findings from the Nun Study, Neurobiol. Aging, 2005, vol. 26, pp. 341–347.PubMedCrossRefGoogle Scholar
  37. 37.
    Samaras, T.T., Should We Be Concerned over Increasing Body Height and Weight?, Exp. Gerontol., 2009, vol. 44, pp. 83–92.PubMedCrossRefGoogle Scholar
  38. 38.
    Sherwin, C.M., Voluntary Wheel Running: A Review and Novel Interpretation, Animal Behav., 1998, vol. 56, pp. 11–27.CrossRefGoogle Scholar
  39. 39.
    Shkolnikov, V.M., Andreev, E.M., Leon, D.A., et al., Mortality Reversal in Russia: The Story so Far, Hygiea Int., 2004, vol. 4, pp. 29–80.CrossRefGoogle Scholar
  40. 40.
    Thompson, L.V., Age-Related Muscle Dysfunction, Exp. Geront., 2008, doi: 10.1016/j.exger.2008.05.003.Google Scholar
  41. 41.
    Thune, I. and Furberg, A.S., Physical Activity and Cancer Risk: Dose-Response and Cancer, All Sites and Site-Specific, Med. Sci. Sports Exerc., 2001, vol. 33, pp. 530–550.CrossRefGoogle Scholar
  42. 42.
    Wachter, K.W., Hazard Curves and Life Span Prospects, Pop. Dev. Rev., 2003, vol. 29.Suppl.: Life Span: Evolutionary, Ecological, and Demographic Perspectives, pp. 270–291.Google Scholar
  43. 43.
    Wilmoth, J.R. and Robine, J.-M., The World Trend in Maximum Life Span, Popul. Dev. Rev., 2003, vol. 29.Google Scholar
  44. 44.
    Wilmoth, J.R., Deegan, L.J., Lundstrom, H., and Horiuchi, S., Increase of Maximum Life-Span in Sweden, 1861–1999, Science, 2000, vol. 289, pp. 2366–2368.PubMedCrossRefGoogle Scholar
  45. 45.
    Wolkow, C.A., Identifying Factors that Promote Functional Aging in Caenorhabditis elegans, Exp. Geront., 2006, vol. 41, pp. 1001–1006.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  1. 1.Institute of Experimental MedicineRussian Academy of Medical SciencesSt. PetersburgRussia

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