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Advances in Gerontology

, Volume 2, Issue 4, pp 312–318 | Cite as

Light pollution increases in the morbidity and mortality rates from different causes in male rats

  • A. V. BukalevEmail author
  • I. A. Vinogradova
  • M. A. Zabezhinskii
  • A. V. Semenchenko
  • V. N. Anisimov
Article

Abstract

This paper investigates the effects of different light regimes (constant light, LL; constant darkness, DD; standard light regime, LD; 12 h light/12 h darkness, natural light of northwest Russia, NL) on the dynamics of lifetime morbidity, spontaneous carcinogenesis, and the incidence of certain types of nontumorous pathologies that were identified during autopsy of male rats. As well, it was found that keeping the animals from the age of 25 days under conditions of LL and NL led to an increased frequency of infectious diseases, significantly more rapid development of spontaneous tumors, and expansion of the range and frequency of non-neoplastic diseases as compared with animals that were under standard light conditions (LD). Light deprivation (DD) contributed to a significant reduction of the incidence of neoplasm, non-neoplastic, and infectious diseases as compared with rats that were kept under standard lighting.

Keywords

light regime infectious diseases non-neoplastic pathology rats 

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References

  1. 1.
    Anisimov, V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Senescence), St. Petersburg: Nauka, 2008, vol. 1.Google Scholar
  2. 2.
    Anisimov, V.N. and Vinogradova, I.A., Illumination Regime, Melatonin and Risk of Cancer Development, Vopr. Onkol., 2006, vol. 52, no. 5, pp. 491–498.PubMedGoogle Scholar
  3. 3.
    Anisimov, V.N. and Vinogradova, I.A., Starenie zhenskoi reproduktivnoi sistemy i melatonin (Senescence of Woman’s Reproductive System and Melatonin), St. Petersburg: Sistema, 2008.Google Scholar
  4. 4.
    Vinogradova, I.A., The Influence of Different Illumination Sources on Parameters of Biological Age and Development of Age-Related Pathology in Rats, Med. Akad. Zh., 2005, no. 2, suppl. 6, pp. 16–18.Google Scholar
  5. 5.
    Vinogradova, I.A., The Influence of Illumination Regime on Development of Metabolic Syndrome in Rats during Senescence, Uspekhi Gerontol., 2007, vol. 20, no. 2, pp. 70–75.Google Scholar
  6. 6.
    Vinogradova, I.A., Bukalev, A.V., Zabezhinskii, M.A., et al., The Influence of Illumination Regime and Melatonin on Homeostasis, Lafe Duration and Development of Spontaneous Carcinogenesis in Rat Males, Vopr. Onkol., 2008, vol. 54, no. 1, pp. 70–77.PubMedGoogle Scholar
  7. 7.
    Zamorskii, I.I. and Pishak, V.P., Functional Organization of Photoperiodic System of the Brain, Usp. Fiziol. Nauk, 2003, vol. 34, no. 4, pp. 37–53.PubMedGoogle Scholar
  8. 8.
    Komarov, F.I., Rapoport, S.I., Malinovskaya, N.K., and Anisimov, V.N., Melatonin v norme i patologii (Melatonin in Norm and Pathology), Moscow: ID Medpraktika-M, 2004.Google Scholar
  9. 9.
    Anisimov, V.N. and Hansen, J., Light, Endocrine Systems and Cancer—A Meeting Report, Neuroendocrinol. Lett., 2002, vol. 23, suppl. 2, pp. 78–81.Google Scholar
  10. 10.
    Anisimov, V.N., Baturin, D.A., Popovich, I.G., et al., Effect of Exposure to Light-at-Night on Life Span and Spontaneous Carcinogenesis in Female CBA Mice, Int. J. Cancer, 2004, vol. 111, pp. 475–479.PubMedCrossRefGoogle Scholar
  11. 11.
    Baturin, D.A., Alimova, I.N., Anisimov, V.N., et al., Effect of Light Regime and Melatonin on the Development of Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice Is Related to a Downregulation of HER-2/neu Gene Expression, Neuroendocrinol. Lett., 2001, vol. 22, pp. 439–445.Google Scholar
  12. 12.
    Cos, S., Mediavilla, D., Martinez-Campa, C., et al., Exposure to Light-at-Night Increases the Growth of DMBA-Induced Mammary Adenocarcinomas in Ruts, Sancer Lett., 2006, vol. 235, pp. 266–271.CrossRefGoogle Scholar
  13. 13.
    Fu, L. and Lee, C.C., The Circadian Clock: Pacemaker and Tumor Suppressor, Nature Rev. Caner., 2003, vol. 3, pp. 350–361.CrossRefGoogle Scholar
  14. 14.
    Hansen, J., Risk of Breast Cancer after Night and Shift Work: Current Evidence and Ongoing Studies in Denmark, Cancer Causes Control, 2006, vol. 17, pp. 531–537.PubMedCrossRefGoogle Scholar
  15. 15.
    Pauley, S.M., Lighting for the Human Circadian Clock: Recent Research Indicates that Lighting Has Become a Public Health Issue, Med. Hypotheses, 2004, vol. 63, pp. 588–596.PubMedCrossRefGoogle Scholar
  16. 16.
    Raitier, M.N., Proposed Role of Septohippocampal and Pallidohabenuloraphe Systems in Photoperiodic Time Measurement, Med. Hypotheses, 1992, vol. 38, pp. 229–235.CrossRefGoogle Scholar
  17. 17.
    Schernhammer, E.S., Laden, F., Speizer, F.E., et al., Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses’ Health Study, J. Natl. Cancer Inst., 2001, vol. 93, pp. 1563–1568.PubMedCrossRefGoogle Scholar
  18. 18.
    Van der Heilignerberg, S., Depres-Brummer, P., Barbason, H., et al., The Tumor Promoting Effect of Constant Light Exposure on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats, Life Sci., 1999, vol. 64, pp. 2523–2534.CrossRefGoogle Scholar
  19. 19.
    Vinogradova, I.A., Anismov, V.N., Bukalev, A.V., et al., Circadian Disruption Induced by Light-at-Night Accelerates Ages and Promotes Tumorigenesis in Rats, Aging (Albany, N.Y.), 2009, vol. 1, no. 10, pp. 1–11.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • A. V. Bukalev
    • 1
    Email author
  • I. A. Vinogradova
    • 2
  • M. A. Zabezhinskii
    • 3
  • A. V. Semenchenko
    • 3
  • V. N. Anisimov
    • 3
  1. 1.Baranov Republic HospitalPetrozavodsk, Republic of KareliaRussia
  2. 2.Petrozavodsk State UniversityPetrozavodsk, Republic of KareliaRussia
  3. 3.Petrov Research Institute of OncologySt. PetersburgRussia

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