Light pollution increases in the morbidity and mortality rates from different causes in male rats
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This paper investigates the effects of different light regimes (constant light, LL; constant darkness, DD; standard light regime, LD; 12 h light/12 h darkness, natural light of northwest Russia, NL) on the dynamics of lifetime morbidity, spontaneous carcinogenesis, and the incidence of certain types of nontumorous pathologies that were identified during autopsy of male rats. As well, it was found that keeping the animals from the age of 25 days under conditions of LL and NL led to an increased frequency of infectious diseases, significantly more rapid development of spontaneous tumors, and expansion of the range and frequency of non-neoplastic diseases as compared with animals that were under standard light conditions (LD). Light deprivation (DD) contributed to a significant reduction of the incidence of neoplasm, non-neoplastic, and infectious diseases as compared with rats that were kept under standard lighting.
Keywordslight regime infectious diseases non-neoplastic pathology rats
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- 1.Anisimov, V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Senescence), St. Petersburg: Nauka, 2008, vol. 1.Google Scholar
- 3.Anisimov, V.N. and Vinogradova, I.A., Starenie zhenskoi reproduktivnoi sistemy i melatonin (Senescence of Woman’s Reproductive System and Melatonin), St. Petersburg: Sistema, 2008.Google Scholar
- 4.Vinogradova, I.A., The Influence of Different Illumination Sources on Parameters of Biological Age and Development of Age-Related Pathology in Rats, Med. Akad. Zh., 2005, no. 2, suppl. 6, pp. 16–18.Google Scholar
- 5.Vinogradova, I.A., The Influence of Illumination Regime on Development of Metabolic Syndrome in Rats during Senescence, Uspekhi Gerontol., 2007, vol. 20, no. 2, pp. 70–75.Google Scholar
- 8.Komarov, F.I., Rapoport, S.I., Malinovskaya, N.K., and Anisimov, V.N., Melatonin v norme i patologii (Melatonin in Norm and Pathology), Moscow: ID Medpraktika-M, 2004.Google Scholar
- 9.Anisimov, V.N. and Hansen, J., Light, Endocrine Systems and Cancer—A Meeting Report, Neuroendocrinol. Lett., 2002, vol. 23, suppl. 2, pp. 78–81.Google Scholar
- 11.Baturin, D.A., Alimova, I.N., Anisimov, V.N., et al., Effect of Light Regime and Melatonin on the Development of Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice Is Related to a Downregulation of HER-2/neu Gene Expression, Neuroendocrinol. Lett., 2001, vol. 22, pp. 439–445.Google Scholar
- 19.Vinogradova, I.A., Anismov, V.N., Bukalev, A.V., et al., Circadian Disruption Induced by Light-at-Night Accelerates Ages and Promotes Tumorigenesis in Rats, Aging (Albany, N.Y.), 2009, vol. 1, no. 10, pp. 1–11.Google Scholar