Advances in Gerontology

, Volume 2, Issue 4, pp 312–318 | Cite as

Light pollution increases in the morbidity and mortality rates from different causes in male rats

  • A. V. BukalevEmail author
  • I. A. Vinogradova
  • M. A. Zabezhinskii
  • A. V. Semenchenko
  • V. N. Anisimov


This paper investigates the effects of different light regimes (constant light, LL; constant darkness, DD; standard light regime, LD; 12 h light/12 h darkness, natural light of northwest Russia, NL) on the dynamics of lifetime morbidity, spontaneous carcinogenesis, and the incidence of certain types of nontumorous pathologies that were identified during autopsy of male rats. As well, it was found that keeping the animals from the age of 25 days under conditions of LL and NL led to an increased frequency of infectious diseases, significantly more rapid development of spontaneous tumors, and expansion of the range and frequency of non-neoplastic diseases as compared with animals that were under standard light conditions (LD). Light deprivation (DD) contributed to a significant reduction of the incidence of neoplasm, non-neoplastic, and infectious diseases as compared with rats that were kept under standard lighting.


light regime infectious diseases non-neoplastic pathology rats 


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© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • A. V. Bukalev
    • 1
    Email author
  • I. A. Vinogradova
    • 2
  • M. A. Zabezhinskii
    • 3
  • A. V. Semenchenko
    • 3
  • V. N. Anisimov
    • 3
  1. 1.Baranov Republic HospitalPetrozavodsk, Republic of KareliaRussia
  2. 2.Petrozavodsk State UniversityPetrozavodsk, Republic of KareliaRussia
  3. 3.Petrov Research Institute of OncologySt. PetersburgRussia

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