Influence of peptides from pineal gland on thymus function with aging

  • N. S. Linkova
  • V. O. Polyakova
  • A. V. Trofimov
  • N. N. Sevostianova
  • I. M. KvetnoyEmail author


This review considers the mutual influence of the thymus and pineal gland on each other during their involution. Research data on the influence of thymus peptides on the pineal gland and of pineal peptides on the thymus is summarized. An analysis of the data showed that pineal peptides (epithalamin, epitalon) had more a effective geroprotective effect on thymus involution in comparison with the geroprotective effect of thymic peptides (thymalin, thymogen) on the involution of the pineal gland. The key mechanisms of pineal peptides’ effect on thymus dystrophy is immunoendocrine cooperation, which is realized via transcription activation of various proteins.


epitalon epithalamin thymus pineal gland aging 


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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • N. S. Linkova
    • 1
  • V. O. Polyakova
    • 1
  • A. V. Trofimov
    • 1
  • N. N. Sevostianova
    • 1
  • I. M. Kvetnoy
    • 1
    Email author
  1. 1.St. Petersburg Institute of Bioregulation and GerontologyNorthwest Branch of the Russian Academy of Medical SciencesSt. PetersburgRussia

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