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Biocompatibility of Biodegradable Polymer Films Based on Poly(lactic-co-glycolic acid) of Various Molecular Weights

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Inorganic Materials: Applied Research Aims and scope

Abstract

Various poly(lactic-co-glycolic acid)-based polymeric films with various molecular weights were obtained. The mechanical characteristics of these films were investigated. It was shown that the obtained polymer films do not have a short-term toxic effect on mammalian cells. The percentage of actively dividing cells on such polymer films is 1.5–3.0 times higher than when grown on culture glass, and, accordingly, the cell layer is formed faster. The obtained poly(lactic-co-glycolic acid)-based polymer films are biocompatible.

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REFERENCES

  1. Zia, K.M., Noreen, A., Zuber, M., Tabasum, S., and Mujahid, M., Recent developments and future prospects on bio-based polyesters derived from renewable resources: a review, Int. J. Biol. Macromol., 2016, vol. 82, pp. 1028–1040.

    Article  CAS  PubMed  Google Scholar 

  2. Sapra, S., Stewart, J.A., Mraud, K., and Schupp, R., A Canadian study of the use of poly-L-lactic acid dermal implant for the treatment of hill and valley acne scarring, Dermatol. Surg., 2015, vol. 41, no. 5, pp. 587–594.

    Article  CAS  PubMed  Google Scholar 

  3. Sevost’yanov, M.A., Fedotov, A.Yu., Nasakina, E.O., Teterina, A.Yu., Baikin, A.S., Sergienko, K.V., Kolmakov, A.G., Komlev, V.S., Ivanov, V.E., Karp, O.E., Gudkov, S.V., and Barinov, S.M., Kinetics of the release of antibiotics from chitosan-based biodegradable biopolymer membranes, Dokl. Chem., 2013, vol. 465, no. 1, pp. 278–280.

    Article  CAS  Google Scholar 

  4. Shue, L., Yufeng, Z., and Mony, U., Biomaterials for periodontal regeneration: a review of ceramics and polymers, Biomatter, 2012, vol. 2, no. 4, pp. 271–277.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lai, P., Daear, W., Löbenberg, R., and Prenner, E.J., Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(D,L-lactide-co-glycolic acid) and polyalkylcyanoacrylate, Colloids Surf., B, 2014, vol. 118, pp. 154–163.

    Article  CAS  Google Scholar 

  6. Charyshkin, A.L., Glushchenko, L.V., Chvalun, S.N., and Sedush, N.S., The first results of the study of self-soluble cava filter, Khirurgiya, 2014, no. 10, pp. 21–24.

  7. Glotova, V.N., Novikov, V.T., Izhenbina, T.N., and Titova, N.G., Solubility of lactide and glycolide in organic solvents, Polzunovskii Vestn., 2014, no. 3, pp. 145–147.

  8. Kaihara, S., Matsumura, S., Mikos, A.G., and Fisher, J.P., Synthesis of poly (L-lactide) and polyglycolide by ring-opening polymerization, Nat. Protoc., 2007, vol. 2, pp. 2767–2771.

    Article  CAS  PubMed  Google Scholar 

  9. Timchenko, T.V., Shcherbakova, L.I., and Kompantsev, V.A., Poly(D,L-lactide-co-glycolide): synthesis, properties, and use for development of medical drugs with microcarriers, Sovrem. Probl. Nauki Obraz., 2015, no. 4.

  10. Nasonova, M.V., Khodyrevskaya, Yu.I., Nemoikina, A.L., Mikhailenko, M.Yu., and Kudryavtseva, Yu.A., Optimization of the degradation period and physical-mechanical properties of anti-adhesive membranes based on biodegradable polymers, Vestn. Kemer. Gos. Univ., 2015, vol. 1, no. 2 (62), pp. 65–69.

  11. Sun, Y., Jensen, H., Petersen, N.J., Larsen, S.W., and Ø stergaard, J., Concomitant monitoring of implant formation and drug release of in situ forming poly (lactide-co-glycolide acid) implants in a hydrogel matrix mimicking the subcutis using UV-vis imaging, J. Pharm. Biomed. Anal., 2018, vol. 50, pp. 95–106.

    Article  CAS  Google Scholar 

  12. Zhu, Y., Wang, Z., Zhou, H., Li, L., Zhu, Q., and Zhang, P., An injectable hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair, Mater. Sci. Eng., C, 2017, vol. 80, pp. 326–334.

    Article  CAS  Google Scholar 

  13. Vodeneev, V.A., Zvyagin, A.V., Shilyagina, N.Yu., Kulikov, D.A., Kulikov, A.V., and Gudkov, S.V., Targeted radionuclide therapy: current status and prospects, Genes Cells, 2015, vol. 10, no. 10, pp. 23–29.

    Google Scholar 

  14. Margaroni, M., Agallou, M., Athanasiou, E., Kammona, O., Kiparissides, C., Gaitanaki, C., and Karagouni, E., Vaccination with poly(D,L-lactide-co-glycolide) nanoparticles loaded with soluble Leishmania antigens and modified with a TNFα-mimicking peptide or monophosphoryl lipid A confers protection against experimental visceral leishmaniasis, Int. J. Nanomed., 2017, vol. 12, pp. 6169–6184.

    Article  CAS  Google Scholar 

  15. Gudkov, S.V., Popova, N.R., and Bruskov, V.I., Radio-protective substances: history, trends and prospects, Biophysics (Moscow), 2015, vol. 60, no. 4, pp. 659–667.

    Article  CAS  Google Scholar 

  16. Gudkov, S.V., Andreev, S.N., Barmina, E.V., Bunkin, N.F., Kartabaeva, B.B., Nesvat, A.P., Stepanov, E.V., Taranda, N.I., Khramov, R.N., and Glinushkin, A.P., Effect of visible light on biological objects: physiological and pathophysiological aspects, Phys. Wave Phenom., 2017, vol. 25, pp. 207–213.

    Article  Google Scholar 

  17. Garmash, S.A., Smirnova, V.S., Karp, O.E., Usacheva, A.M., Berezhnov, A.V., Ivanov, V.E., Cher-nikov, A.V., Bruskov, V.I., and Gudkov, S.V., Pro-oxidative, genotoxic and cytotoxic properties of uranyl ions, J. Environ. Radioact., 2014, vol. 127, pp. 163–170.

    Article  CAS  PubMed  Google Scholar 

  18. Sevost’yanov, M.A., Nasakina, E.O., Baikin, A.S., Sergienko, K.V., Konushkin, S.V., Kaplan, M.A., Seregin, A.V., Leonov, A.V., Kozlov, V.A., Shkirin, A.V., Bunkin, N.F., Kolmakov, A.G., Simakov S.V., and Gudkov, S.V., Biocompatibility of new materials based on nano-structured nitinol with titanium and tantalum composite surface layers: experimental analysis in vitro and in vivo, J. Mater. Sci.: Mater. Med., 2018, vol. 29, p. 33.

    Google Scholar 

  19. Nasakina, E.O., Baikin, A.S., Sergienko, K.V., Sevostyanov, M.A., Kolmakov, A.G., Goncharenko, B.A., Zabolotnyi, V.T., Solntsev, K.A., Fadeev, R.S., Fadeeva, I.S., and Gudkov, S.V., Biocompatibility of nanostructured nitinol with titanium or tantalum surface composite layers formed by magnetron sputtering, Dokl. Chem., 2015, vol. 461, no. 1, pp. 86–88.

    Article  CAS  Google Scholar 

  20. Sevost’yanov, M.A., Fedotov, A.Yu., Kolmakov, A.G., Zabolotnyi, V.T., Barinov, S.M., Goncharenko, B.A., Komlev, V.S., Baikin, A.S., Sergienko, K.V., Tete-rina, A.Yu., Nasakina, E.O., Leonova, Yu.O., and Leonov, A.V., Mechanical properties of nanostructured nitinol/chitosan composite material, Inorg. Mater.: Appl. Res., 2014, vol. 5, no. 4, pp. 344–346.

    Article  Google Scholar 

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Funding

This work was supported by the Ministry of Education and Science of the Russian Federation (grant identifier RFMEFI60417X0196).

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Authors and Affiliations

  1. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, 119334, Moscow, Russia

    A. S. Baikin, M. A. Sevost’yanov, E. O. Nasakina, K. V. Sergienko, M. A. Kaplan, S. V. Konushkin, A. A. Kolmakova, A. D. Yakubov, S. M. Barinov & A. G. Kolmakov

  2. Bauman Moscow State Technical University, 105005, Moscow, Russia

    N. F. Bunkin

  3. Prokhorov General Physics Institute, 117942, Moscow, Russia

    N. F. Bunkin & S. V. Gudkov

  4. Lobachevsky State University of Nizhny Novgorod—National Research University, 603950, Nizhny Novgorod, Russia

    S. V. Gudkov

  5. Moscow Regional Research Clinical Institute, 129110, Moscow, Russia

    S. V. Gudkov

  6. Voronezh State Technical University, 394026, Voronezh, Russia

    L. A. Shatova

Authors
  1. A. S. Baikin
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  2. M. A. Sevost’yanov
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  3. E. O. Nasakina
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  4. K. V. Sergienko
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  5. M. A. Kaplan
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  6. S. V. Konushkin
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  7. A. A. Kolmakova
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  8. A. D. Yakubov
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  9. N. F. Bunkin
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  10. S. V. Gudkov
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  11. L. A. Shatova
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  12. S. M. Barinov
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  13. A. G. Kolmakov
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Corresponding author

Correspondence to A. S. Baikin.

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Translated by K. Lazarev

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Baikin, A.S., Sevost’yanov, M.A., Nasakina, E.O. et al. Biocompatibility of Biodegradable Polymer Films Based on Poly(lactic-co-glycolic acid) of Various Molecular Weights. Inorg. Mater. Appl. Res. 10, 887–891 (2019). https://doi.org/10.1134/S207511331904004X

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  • DOI: https://doi.org/10.1134/S207511331904004X

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