Investigation of physicochemical and biological properties of composite matrices in a alginate–calcium phosphate system intended for use in prototyping technologies during replacement of bone defects
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Materials for 3D printing of porous composite materials (CM) that are based on sodium alginate–tricalcium phosphate are developed. Physicochemical and biological studies of CM in vitro are performed using a model of two adherent cells lines, immortalized human fibroblasts (HF, strain 1608h TERT) and human osteosarcoma (MG-63) that are cultivated up to 21 days. The cytocompatibility and matrix properties are studied by an MTT assay.
Keywordsmaterials for osteoplastics composite materials based on alginate–tricalcium phosphate in vitro studies cytocompatibility matrix properties
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- 1.Rodriguez, G.M., Naves, D.M., and Cannata, A.J.B., Bone metabolism, vascular calcifications and mortality: Associations beyond mere coincidence, J. Nephrol., 2005, vol. 18, pp. 458–463.Google Scholar
- 3.Venkatesan, J. and Kim, Se-K., Marine Biomaterials. Springer Handbook of Marine Biotechnology, Berlin: Springer-Verlag, 2015.Google Scholar
- 5.Serino, G., Rao, W., Iezzi, G., and Piattelli, A., Polylactide and polyglycolide sponge used in human extraction sockets: Bone formation following 3 months after its application, Clin. Oral. Implants Res., 2008, vol. 19, no. 1, pp. 26–31.Google Scholar
- 7.Hench, L.L., Bioceramics: From concept to clinic, J. Am. Ceram., 1991, vol. 74, pp. 1487–1510.Google Scholar
- 8.Sarkisov, P.D., Mikhailenko, N.Yu., and Khavala, V.M., Biologicheskaya aktivnost’ materialov na osnove stekla i sistallov, Steklo Keram., 1993, vol. 9, pp. 10–16.Google Scholar
- 12.Kundu, J., Pati, F., Shim, J.-H., and Cho, D.-W., Rapid Prototyping Technology for Bone Regeneration. Principles and Applications Cambridge: Woodhead, 2014.Google Scholar