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Abstract—The article presents theresults of a biosafety study of two gadolinium nanocomposites encapsulated in the natural polymer matrix of arabinogalactan and gives a comparative assessment of their toxicity. A probe was used to administer per os white outbred male rats with a solution of the studied nanocomposites in a dose of 500 μg gadolinium per kilogram of animal body weight. Histological and immunohistochemical analysis was applied to assay the severity of an organism’s biological response to these introduced nanocomposites. The state of liver tissue and the sensorimotor cortex were evaluated. In brain tissue, the number of neurons with expression of proapoptotic caspase 3 protein, antiapoptotic bcl-2 protein, and HSP stress protein 70 were determined. The authors determined the general points of application of the pathological process under the action of the studied nanocomposites and individual features of formation of the pathological process for each nanocomposite.

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Titov, E.A., Sosedova, L.M. & Novikov, M.A. ANALYSIS OF THE TOXICITY OF GADOLINIUM NANOCOMPOSITES. Nanotechnol Russia 14, 144–148 (2019).

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