Abstract
For the culture of normal and transformed fibroblasts, the differential effect of two nanoclusters (Мо72Fe30, Мо132) has been shown. The Мо72Fe30 nanocluster is nontoxic to normal fibroblasts, while the Мо132 cluster shows toxicity to normal and transformed fibroblasts. An analysis of the ultrastructure of the cells under the influence of the nanoclusters has demonstrated the specificity of the changes. The dermal fibroblasts are more resistant to the action of Мо72Fe30; the Мо132 cluster causes extensive disorders in the membrane organelles both in normal and transformed fibroblasts. The results confirm the possibility of applying the Мо72Fe30 nanocluster in biomedicine and the use of the Мо132 nanocluster in oncology.
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Original Russian Text © A.A. Ostroushko, M.V. Ulitko, M.O. Tonkushina, I.V. Zubarev, S.Yu. Medvedeva, I.G. Danilova, O.V. Gubaeva, I.D. Gagarin, I.F. Gette, 2018, published in Rossiiskie Nanotekhnologii, 2018, Vol. 13, Nos. 1–2.
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Ostroushko, A.A., Ulitko, M.V., Tonkushina, M.O. et al. Influence of Nanocluster Molybdenum Polyoxometalates on the Morphofunctional State of Fibroblasts in Culture. Nanotechnol Russia 13, 1–10 (2018). https://doi.org/10.1134/S199507801801010X
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DOI: https://doi.org/10.1134/S199507801801010X