Preparation and physicochemical properties of Nicotinamide@AlOOH biocompatible composite based on sol-gel materials
- 55 Downloads
This paper is devoted to studying the properties of the functional nanocomposite nicotinamide@boehmite. Nicotinamide is introduced directly into a sol of boehmite with the subsequent aging and drying. The results of obtaining high-purity boehmite sol prepared with the use of ultrasonic machining as a physical method of peptization are presented. The structure of the composite is studied with the help of a complex of methods: X-ray-phase analysis, IR-spectroscopy, electron microscopy, and the low-temperature adsorption-desorption of nitrogen. The release of nicotinamide is studied in a histidine buffer at pH = 7.4. Forty-eight percent of the introduced nicotinamide is released in the first 2 h with subsequent sharp retardation resulting in a complete release for a long time.
KeywordsNicotinamide Boehmite Prolonged Release Inorganic Polymer Valent Vibration
Unable to display preview. Download preview PDF.
- 6.L. Siemenska, M. Ferguson, T. W. Zerda, and E. J. Couch, Sol-Gel Sci. Technol. 8, 1105 (1997).Google Scholar
- 14.M. Amoura, N. Nassif, C. Roux, J. Livage, and T. Coradin, Chem. Commun., 4015 (2007).Google Scholar
- 27.C. J. Brinker and G. W. Scherer, Sol-Gel Science: the Physics and Chemistry of Sol-Gel Processing (Acad. Press, San Diego, 1990), pp. 212–213.Google Scholar
- 28.B. E. Yoldas, Am. Ceram. Soc. Bull. 54, 289 (1975).Google Scholar
- 32.N. Z. Wu, D. Da, T. L. Rudoll, D. Needham, A. R. Whorton, and M. W. Dewhirst, Cancer Res. 53(16), 3765 (1993).Google Scholar