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Furodihydroquinolines as Novel Photosensitizers for Photochemotherapy


New derivatives of furodihydroquinoline (FDHQ) with substituents at the 5 position of the benzene ring have been synthesized, and their photophysical and photochemical properties have been studied. The triplet nature of short-lived states generated on photoexcitation of FDHQ has been shown with the use of pulse photolysis and triplet–triplet energy transfer to biscarbocyanine dye. Spectral and kinetic parameters of the triplet states for the synthesized FDHQ have been established. It has been shown that the FDHQ triplet state participates in the formation of the reactive oxygen species (ROS). Processes involving the FDHQ triplet state are important for PUVA-therapy and other processes of photochemotherapy.

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The spectral measurements were carried out in the Core Facility of IBCP RAS “New Materials and Technologies.”


The study was supported by the Russian Scientific Foundation, project no. 18-13-00463 “Mechanisms of Photochemical Processes in the Complexes of Polymethine Dyes with Two-conjugated Chromophores with Proteins.”

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Correspondence to V. A. Kuzmin.

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Translated by T. Nekipelova

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Kuzmin, V.A., Volnukhin, V.A., Egorov, A.E. et al. Furodihydroquinolines as Novel Photosensitizers for Photochemotherapy. Russ. J. Phys. Chem. B 13, 893–899 (2019).

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  • photochemistry
  • triplet states
  • furodihydroquinolines
  • photochemotherapy
  • PUVA-therapy