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Antioxidant and Antiglication Properties of 6-Hydroxy-2-Aminobenzothiazole N-Acetylcysteinate

Abstract

The antioxidant and antiglycation activity of the water-soluble heterocyclic antioxidant 6‑hydroxy-2-aminobenzothiazole N-acetylcysteinate (HABTI ACC) has been studied. The high antiradical activity of this substance has been found by the chemiluminescence method. HABTI ACC has been found to show the high antioxidant activity in the peroxidation of photoreceptor cells induced by ultraviolet radiation, ferrous ions, and visible light in the presence of age pigment lipofuscin or its A2E fluorophore. HABTI ACC effectively inhibits the fructosylation of serum albumin and proteins of photoreceptor cells. The HABTI ACC inhibitory ability in the process of fructose albumin modification is comparable with the aminoguanidine and pyridoxamine activity, the known antiglycation compounds, and is much higher than that of mexidol. It is suggested that the use of this compound is promising in pharmacological practice for the prevention and treatment of metabolic syndrome.

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Correspondence to N. L. Sakina.

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Translated by V. Avdeeva

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Dontsov, A.E., Sakina, N.L., Kuznetsov, Y.V. et al. Antioxidant and Antiglication Properties of 6-Hydroxy-2-Aminobenzothiazole N-Acetylcysteinate. Russ. J. Phys. Chem. B 13, 947–950 (2019). https://doi.org/10.1134/S1990793119060174

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Keywords:

  • heteroaromatic antioxidants
  • lipid peroxidation
  • antiglycation activity
  • photoprotective properties