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Anti-mullerian hormone receptor type II as a Potential Target for Antineoplastic Therapy

  • A. Ya. RakEmail author
  • A. V. Trofimov
  • A. M. Ischenko
Article
  • 3 Downloads

Abstract

The review considers properties of anti-Mullerian hormone receptor type II (also known as Mullerian inhibiting substance receptor type II, MISRII), a transmembrane sensor, exhibiting own serine/threonine protein kinase activity, triggering apoptosis of Mullerian duct cells in mammalian embryogenesis and providing formation of the male-type reproductive system. According to recent data, MISRII overexpression in the postnatal period has been found in cells of a number of ovarian, mammary gland, and prostate tumors, and anti-Mullerian hormone (AMH) has a proapoptotic effect on MISRII-positive tumor cells. This fact makes MISRII a potential target for targeted antineoplastic therapy. Treatment based on MISRII targeting seems to be a much more effective alternative to the traditional one and will significantly reduce the dose of pharmacological agent due to its targeted delivery to malignant cells. In addition, antibodies specific to MISRII may be used to diagnose the malignances. However, the mechanism of MISRII-AMH interaction is still poorly understood and this complicates development of new anticancer drugs. The review considers molecular structure and expression levels of MISRII in various tissues and cell lines, as well as current knowledge on mechanisms of AMH receptor binding and data on the possibility of using MISRII as a target for the action of AMH-based antineoplastic drugs or MISRII specific antibodies.

Keywords:

anti-Mullerian hormone antineoplastic therapy receptor signaling pathway MISRII AMHR2 

Notes

COMPLIANCE WITH ETHICAL STANDARDS

Conflict of interests. The authors declare that they have no conflict of interest.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. Ya. Rak
    • 1
    • 2
    Email author
  • A. V. Trofimov
    • 1
  • A. M. Ischenko
    • 1
  1. 1.State Research Institute for Highly Pure BiopreparationsSaint-PetersburgRussia
  2. 2.Saint-Petersburg State UniversitySaint-PetersburgRussia

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