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CLEC-2-Induced Signaling in Blood Platelets

  • A. A. MartyanovEmail author
  • V. N. Kaneva
  • M. A. Panteleev
  • A. N. Sveshnikova
Article
  • 11 Downloads

Abstract

Platelet activating lectin-like receptor type C-2 (CLEC-2) has been identified on the platelet surface about a decade ago. The only known endogenous CLEC-2 agonist is podoplanin, a transmembrane protein expressed by lymphatic endothelial cells, lymph node fibroblastic reticular cells, kidney podocytes, and by cells of certain tumors. CLEC-2 and podoplanin are involved in metastases, sepsis, development of deep-vein thrombosis. The CLEC-2 signaling cascade includes tyrosine kinases (Syk, SFK, Btk) as well as LAT adapter, and phospholipase Cγ2, which induces calcium signalling. CLEC-2, podoplanin and proteins, participating in the CLEC-2 signalling cascade, are considered as perspective targets for antithrombotic therapy.

Keywords:

platelet CLEC-2 receptor tyrosine kinases lymphangiogenesis metastasis podoplanin 

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. A. Martyanov
    • 1
    • 2
    Email author
  • V. N. Kaneva
    • 1
    • 3
  • M. A. Panteleev
    • 2
    • 3
  • A. N. Sveshnikova
    • 1
    • 2
  1. 1.Faculty of Physics, Moscow State UniversityMoscowRussia
  2. 2.Center for Theoretical Problems of Physicochemical PharmacologyMoscowRussia
  3. 3.Rogachev National Scientific and Practical Centre of Pediatric Hematology, Oncology and ImmunologyMoscowRussia

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