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Prospects for the Use of Gene Expression Analysis in Rheumatology

  • E. V. ChetinaEmail author
  • G. A. Markova
Article
  • 5 Downloads

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology, characterized by disturbances in functioning of immune system signaling pathways. This is accompanied by injury of other tissues, pain and joint destruction. Modern treatment is aimed at correction of pathophysiological and biochemical mechanisms responsible for clinical manifestation of the disease. However, due to heterogeneity of RA patients there is a clear need in the personalized approach to the RA treatment; the choice of personalized treatment is complicated by the variability of RA patient responses to the therapy. Gene expression analysis may serve as a tool for the disease control and therapy personification, for inhibition of inflammation and pain as well as for prevention of joint destruction.

Keywords:

rheumatic diseases gene expression proinflammatory cytokines pain 

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Nasonova Research Institute of RheumatologyMoscowRussia

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