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Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain

  • M. I. AirapetovEmail author
  • E. A. Sekste
  • S. O. Eresko
  • E. R. Bychkov
  • A. A. Lebedev
  • P. D. Shabanov
Article
  • 6 Downloads

Abstract

Orexin and its receptors are involved in mechanisms of pathological craving to alcohol. This study has shown that the mRNA level of the orexin receptor type 1 (OX1R) significantly decreased in the prefrontal cortex in the group of chronically alcoholized (for 6 months) rats compared with intact control. The same changes in the OX1R gene expression were observed on day 1 and day 7 of alcohol withdrawal after chronic alcoholization. On the contrary, in the hippocampus, the OX1R mRNA level increased on day 1 and day 7 of alcohol withdrawal. In the ventral tegmental area, the OX1R mRNA level remained unchanged on both day 1 and day 7 of alcohol withdrawal compared with the groups of chronic alcoholization and intact control. This suggests involvement of the prefrontal cortex and hippocampus in mechanisms mediating chronic alcohol intoxication.

Key words:

alcoholism neuropeptides orexin OX1R 

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • M. I. Airapetov
    • 1
    • 2
    Email author
  • E. A. Sekste
    • 1
  • S. O. Eresko
    • 3
  • E. R. Bychkov
    • 1
  • A. A. Lebedev
    • 1
  • P. D. Shabanov
    • 1
    • 3
    • 4
  1. 1.Institute of Experimental Medicine (IEM)St. PetersburgRussia
  2. 2.St. Petersburg State Medical Pediatric UniversitySt. PetersburgRussia
  3. 3.St. Petersburg State UniversitySt. PetersburgRussia
  4. 4.Kirov Military Medical AcademySt. PetersburgRussia

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