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Pharmacological Targets for Correction of Dyslipidemias. Opportunities and Prospects of Therapeutic Use

  • V. A. Kudinov
  • T. S. Zakharova
  • T. I. Torkhovskaya
  • O. M. Ipatova
  • A. I. Archakov
Article
  • 20 Downloads

Abstract

The review summarizes literature data on existing pharmacological agents and novel drug preparations developed for correction of dyslipidemias and molecular mechanisms of their action. Much attention is paid to analysis of experimental and clinical studies aimed at identification of new pharmacological targets for correction of dyslipidemias and characterization of approaches increasing high density lipoproteins functionality. The implementation of alternative pharmacological agents with new alternative mechanisms of action may improve the effectiveness of traditional treatment in the future.

Keywords

cholesterol atherosclerosis high density lipoproteins reverse cholesterol transport macrophages hypolipidemic agents 

Abbreviations

ABCA1

ATP-binding cassette transporter A1

ABCG1

ATP-binding cassette transporter G1

ABCG5

ATP-binding cassette transporter G5

ABCG8

ATP-binding cassette transporter G8

ACS

acute coronary syndrome

AP2

Adaptor protein 2

Apo A-1

apolipoprotein A-1

Apo B

apolipoprotein B

BD2

Bromodomain 2

BET

Bromodomain and extra-terminal domain

B-PAV

Baseline percent atheroma volume

CETP

Cholesterol ester transfer protein

CEC

Cholesterol efflux capacity

Chol

cholesterol

CholE

cholesterol esters

CVDs

cardiovascular diseases

DGAT2

Diacylglycerol acyltransferase 2

FA

fatty acids

FAMP

Fukuoka University ApoA-I Mimetic Peptide

FXR

Farnesoid X receptor)

GIT

gastrointestinal tract

HCA

Hyocholic acid)

HDCA

Hyodeoxycholic acid

HDL

high density lipoproteins

HDL-C

high-density lipoprotein cholesterol

HDLR

high density lipoprotein receptors

HMG-CoA reductase

β-hydroxy-β-methyl glutarylcoenzyme A reductase

LDL

low density lipoproteins

LDLR

low density lipoprotein receptors

LDL-C

low-density lipoprotein cholesterol

LPA

lysophosphatidic acid

LXR

Liver X receptors

MACE

Major Adverse Cardiac Events

MHC II

Major histocompatibility complex class II

NOS

Nitric oxide synthase

NPC1L1

Niemann-Pick C1-like 1 protein

PCh

phosphatidylcholine

PCSK9

Proprotein convertase subtilisin/kexin type 9

PL

phospholipids

PPAR

Peroxisome proliferator-activated receptors

RCT

reverse cholesterol transport

SRB1

Scavenger receptor class B member 1

SREBR-2

Sterol regulatory element- binding protein 2

TGR5

Transmembrane G protein coupled bile acid receptor

TG

triglycerides

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • V. A. Kudinov
    • 1
  • T. S. Zakharova
    • 1
  • T. I. Torkhovskaya
    • 1
  • O. M. Ipatova
    • 1
  • A. I. Archakov
    • 1
  1. 1.Institute of Biomedical Chemistry (IBMC)MoscowRussia

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