Pharmacological Targets for Correction of Dyslipidemias. Opportunities and Prospects of Therapeutic Use

  • V. A. Kudinov
  • T. S. Zakharova
  • T. I. Torkhovskaya
  • O. M. Ipatova
  • A. I. Archakov


The review summarizes literature data on existing pharmacological agents and novel drug preparations developed for correction of dyslipidemias and molecular mechanisms of their action. Much attention is paid to analysis of experimental and clinical studies aimed at identification of new pharmacological targets for correction of dyslipidemias and characterization of approaches increasing high density lipoproteins functionality. The implementation of alternative pharmacological agents with new alternative mechanisms of action may improve the effectiveness of traditional treatment in the future.


cholesterol atherosclerosis high density lipoproteins reverse cholesterol transport macrophages hypolipidemic agents 



ATP-binding cassette transporter A1


ATP-binding cassette transporter G1


ATP-binding cassette transporter G5


ATP-binding cassette transporter G8


acute coronary syndrome


Adaptor protein 2

Apo A-1

apolipoprotein A-1

Apo B

apolipoprotein B


Bromodomain 2


Bromodomain and extra-terminal domain


Baseline percent atheroma volume


Cholesterol ester transfer protein


Cholesterol efflux capacity




cholesterol esters


cardiovascular diseases


Diacylglycerol acyltransferase 2


fatty acids


Fukuoka University ApoA-I Mimetic Peptide


Farnesoid X receptor)


gastrointestinal tract


Hyocholic acid)


Hyodeoxycholic acid


high density lipoproteins


high-density lipoprotein cholesterol


high density lipoprotein receptors

HMG-CoA reductase

β-hydroxy-β-methyl glutarylcoenzyme A reductase


low density lipoproteins


low density lipoprotein receptors


low-density lipoprotein cholesterol


lysophosphatidic acid


Liver X receptors


Major Adverse Cardiac Events


Major histocompatibility complex class II


Nitric oxide synthase


Niemann-Pick C1-like 1 protein




Proprotein convertase subtilisin/kexin type 9




Peroxisome proliferator-activated receptors


reverse cholesterol transport


Scavenger receptor class B member 1


Sterol regulatory element- binding protein 2


Transmembrane G protein coupled bile acid receptor




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  1. 1.
    Nelson, R.H., Prim. Care, 2013, vol. 40, no. 1, pp. 195–211.CrossRefPubMedGoogle Scholar
  2. 2.
    Diagnostika i korretsiya narusheniy lipidnogo obmena s tsel’yu profilaktiki i lecheniya ateroskleroza (Diagnostics and Correction of Lipid Metabolism Impairments for Prophylaxis and Therapy of Atherosclerosis) Russian Recommendations, VI ed., AiD, 2017, no. 3, pp. 5–22.Google Scholar
  3. 3.
    Klimov, A.N. and Nikulcheva, N.G., Obmen lipidov i lipoproteidov i ego narusheniya (Metabolism of Lipids and Lipoproteins and its Impairments), Saint Petersburg: Piter, 1999.Google Scholar
  4. 4.
    Illter, A., Tusun, E., Besli, F., and Sezen, H., Eur. J. Health Sci., 2016, vol. 2, pp. 15–19.CrossRefGoogle Scholar
  5. 5.
    Baigent, C., Blackwell, L., Emberson, J., Holland, L.E., Reith, C., Bhala, N., et al., Lancet, 2010, vol. 376, pp. 1670–1681.CrossRefPubMedGoogle Scholar
  6. 6.
    Stoekenbroek, R.M., Stroes, E.S., and Hovingh, G.K., Handbook of Experimental Pharmacology, High Density Lipoproteins, Eckardstein, A. and Kardassis, D., Eds., Springer, 2015, vol. 22, pp 633–643.Google Scholar
  7. 7.
    Perez-Mendez, O., Arch. Cardiol Mex., 2004, vol. 74, pp. 53–67.PubMedGoogle Scholar
  8. 8.
    Ikenaga, M., Higaki, Y., Saku, K., and Uehara, Y., J. Atheroscler. Thromb., 2016, vol. 23, pp. 385–394.CrossRefPubMedGoogle Scholar
  9. 9.
    Boden, W.E., Probstfield, J.L., Anderson, T., Chaitman, B.R., Desvignes-Nickens, P., et al., N. Engl. J. Med., 2011, vol. 365, pp. 2255–2267.CrossRefPubMedGoogle Scholar
  10. 10.
    Nissen, S.E., Tardif, J.C., Nicholls, S.J., Revkin, J.H., Shear, C.L., et al., N. Engl. J. Med., 2007, vol. 356, pp. 1304–1316.CrossRefPubMedGoogle Scholar
  11. 11.
    Lim, G.B., Nat. Rev. Cardiol., 2013, vol. 10, 5. doi 10.1038/nrcardio.2012.171CrossRefPubMedGoogle Scholar
  12. 12.
  13. 13.
    HPS2-THRIVE Collaborative Group, Eur. Heart. J., 2013, vol. 34, pp. 1279–1291.CrossRefPubMedCentralGoogle Scholar
  14. 14.
    Keene, D., Price, C., Shun-Shin, M.J., and Francis, D.P., B.M.J., 2014, vol. 349, g4379.CrossRefGoogle Scholar
  15. 15.
    Yamamoto, S., Narito, I., and Kotany, K., Clin. Chim. Acta, 2016, vol. 457, pp. 117–122.CrossRefPubMedGoogle Scholar
  16. 16.
    Mani, P. and Rohatgi, A., Curr. Atheroscler. Rep., 2015, vol. 17, no. 8. doi 10.1007/s11883-015-0521-xGoogle Scholar
  17. 17.
    Couture, P. and Lamarche, B., Curr. Opin. Lipidol., 2013, vol. 24, pp. 227–232.CrossRefPubMedGoogle Scholar
  18. 18.
    Ge, L., Wang, J., Qi, W., et al., Cell Metab., 2008, vol. 7, pp. 508–519.CrossRefPubMedGoogle Scholar
  19. 19.
    Shulutko, B.I. and Makarenko, S.V., Standarty diagnostiki i lecheniya vnutrennikh boleznei (Standards of Diagnostics and Therapy of Internal Diseases), 2007.Google Scholar
  20. 20.
    Joseph, L. and Robinson, J.G., Prog. Cardiovasc. Dis., 2015, vol. 58, no. 1, pp. 19–31.CrossRefPubMedGoogle Scholar
  21. 21.
    Cimmino, G., Ciccarelli, G., Morello, A., Ciccarelli, M., and Golino, P., J. Transl. Med., 2015, vol. 2012, no. 6, pp. 29–40.Google Scholar
  22. 22.
    Gomaraschi, M., Adorni, M.P., Banach, M., Bernini, F., et al., Handbook of Experimental Pharmacology, High Density Lipoproteins, Eckardstein, A. and Kardassis, D., Eds., Springer, 2015, vol. 224, pp. 593–615.CrossRefPubMedGoogle Scholar
  23. 23.
    Norato, G.D., Scientifica (Cairo), 2012, vol. 2012, article ID 482423. doi 10.6064/2012/482423Google Scholar
  24. 24.
    Toth, P.P., Dayspring, T.D., and Pokrywka, G.S., Curr. Atheroscler. Rep., 2009, vol. 11, pp. 71–79.CrossRefPubMedGoogle Scholar
  25. 25.
    Ganji, S.H., Tavintharan, S., Zhu, D., Xing, Y., Kamanna, V.S., and Kashyap, M.L., J. Lipid Res., 2004, vol. 45, pp. 1835–1845.CrossRefPubMedGoogle Scholar
  26. 26.
    Jin, F.Y., Kamanna, V.S., and Kashyap, M.L., Arterioscler. Thromb. Vasc. Biol., 1999, vol. 19, pp. 1051–1059.CrossRefPubMedGoogle Scholar
  27. 27.
    Reiner, Z., Catapano, A.L., Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., et al., Eur. Heart J., 2011, vol. 32, pp. 1769–1818.CrossRefPubMedGoogle Scholar
  28. 28.
    Barter, P.J., Caulfield, M., Eriksson, M., Grundy, S.M., Kastelein, J.J., Komajda, M., et al., N. Engl. J. Med., 2007, vol. 357, pp. 2109–2122.CrossRefPubMedGoogle Scholar
  29. 29.
    Tchoua, U., Gillard, B.K., and Pownall, H.J., Atherosclerosis, 2010, vol. 209, pp. 430–435.CrossRefPubMedGoogle Scholar
  30. 30.
    Jones, P.H., Davidson, M.H., Stein, E.A., Bays, H.E., McKenney, J.M., Miller, E., Cain, V.A., and Blasetto, J.W., Am. J. Cardiol., 2003, vol. 92, pp. 152–160.CrossRefPubMedGoogle Scholar
  31. 31.
    Barter, P.J., Brandrup-Wognsen, G., Palmer, M.C., and Nicholls, S.J., J. Lipid Res., 2010, vol. 51, pp. 1546–1553.CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Tamehiro, N., Shigemoto-Mogami, Y., Kakeya, T., Okuhira, K., Suzuki, K., Sato, R., Nagao, T., and Nishimaki-Mogami, T., J. Biol. Chem., 2007, vol. 282, pp. 21090–21099.CrossRefPubMedGoogle Scholar
  33. 33.
    Kassai, A., Illyes, L., Mirdamadi, H.Z., Seres, I., Kalmar, T., Audikovszky, M., and Paragh, G., Clin. Biochem., 2007, vol. 40, pp. 1–5.CrossRefPubMedGoogle Scholar
  34. 34.
    Kwak, B., Mulhaupt, F., Myit, S., and Mach, F., Nat. Med., 2000, vol. 6, pp. 1399–1402.CrossRefPubMedGoogle Scholar
  35. 35.
    Mulhaupt, F., Matter, C.M., Kwak, B.R., et al., Cardiovasc. Res., 2003, vol. 59, pp. 755–766.CrossRefPubMedGoogle Scholar
  36. 36.
    Haramaki, N., Ikeda, H., Takenaka, K., et al., Arterioscler. Thromb. Vasc. Biol., 2007, vol. 27, pp. 1471–1477.CrossRefPubMedGoogle Scholar
  37. 37.
    Xie, C., Zhou, Z.S., Li, N., et al., J. Lipid Res., 2012, vol. 53, pp. 2092–2101.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Phan, B.A., Dayspring, T.D., and Toth, P.P., Vasc. Health Risk Manag., 2012, vol. 8, pp. 415–427.PubMedPubMedCentralGoogle Scholar
  39. 39.
    Engelking, L.J., McFarlane, M.R., Li, C.K., and Liang, G., J. Lipid Res., 2012, vol. 53, pp. 1359–1368.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Sehayek, E. and Hazen, S.L., Arterioscler. Thromb. Vasc. Biol., 2008, vol. 28, pp. 1296–1297.CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    Davidson, M.H., McGarry, T., Bettis, R., et al., J. Am. Coll. Cardiol., 2002, vol. 40, pp. 2125–2134.CrossRefPubMedGoogle Scholar
  42. 42.
    Kaminnyi, A.I., Lankin, V.Z., Samko, A.N., et al., Byull. Eksper. Biol. Med., 2005, vol. 139, no. 2, pp. 150–152.Google Scholar
  43. 43.
    Wagner, K.-D. and Wagner, N., Pharmacol. Ther., 2010, vol. 125, pp. 423–435.CrossRefPubMedGoogle Scholar
  44. 44.
    Berger, J.P., Akiyama, T.E., and Meinke, P.T., Trends. Pharmacol. Sci., 2005, vol. 26, pp. 244–251.CrossRefPubMedGoogle Scholar
  45. 45.
    Colin S., Chinetti-Gbaguidi G., Kuivenhoven J.A., Staels B., Handbook of Experimental Pharmacology, High Density Lipoproteins, Eckardstein A. and Kardassis, D., Eds., Springer, 2015, vol. 224, pp. 617–626.CrossRefGoogle Scholar
  46. 46.
    Chinetti, G., Fruchart, J.C., and Staels, B., Curr. Opin. Lipidol., 2003, vol. 14, pp. 459–468.CrossRefPubMedGoogle Scholar
  47. 47.
    Chinetti, G., Lestavel, S., Bocher, V., et al., Nat. Med., 2001, vol. 7, pp. 53–58.CrossRefPubMedGoogle Scholar
  48. 48.
    Triolo, M., Annema, W., Boer, J.F., Tietge, U.J., and Dullaart, R.P., Eur. J. Clin. Invest., 2013, vol. 44, pp. 240–248.CrossRefGoogle Scholar
  49. 49.
    Libby, P., Circulation, 2003, vol. 105, pp. 1135–1143.CrossRefGoogle Scholar
  50. 50.
    Wang, T.D., Chen, W.J., Lin, J.W., Cheng, C.C., Chen, M.F., and Lee, Y.T., Atherosclerosis, 2003, vol. 170, pp. 315–323.CrossRefPubMedGoogle Scholar
  51. 51.
    Bouhlel, M.A., Derudas, B., Rigamonti, E., et al., Cell Metab., 2007, vol. 6, pp. 137–143.CrossRefPubMedGoogle Scholar
  52. 52.
    Oliver, W.R., Shenk, J.L., Snaith, M.R., et al., Proc. Natl. Acad. Sci. USA, 2001, vol. 98, pp. 5306–5311.CrossRefPubMedPubMedCentralGoogle Scholar
  53. 53.
    Tanaka, T., Yamamoto, J., Iwasaki, S., et al., Proc. Natl. Acad. Sci. USA, 2003, vol. 100, pp. 15924–15929.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Sahebkar, A., Chew, G.T., and Watts, G.F., Expert Opin. Pharmacother., 2014, vol. 15, pp. 493–503.CrossRefPubMedGoogle Scholar
  55. 55.
    Enger, C., Gately, R., and Ming, E.E., Am. J. Cardiol., 2010, vol. 106, pp. 1594–1601.CrossRefPubMedGoogle Scholar
  56. 56.
    Tontonoz, P., and Spiegelman, B.M., Annu. Rev. Biochem., 2008, vol. 77, pp. 289–312.CrossRefPubMedGoogle Scholar
  57. 57.
    Ju, J.G., Javorschi, S., Hevener, A.L., et al., Diabetes, 2002, vol. 51, pp. 2968–2974.CrossRefGoogle Scholar
  58. 58.
    Man’kovskiy, B.N., Ukr. Med. Vestnik, 2008, vol. 22, no. 1.Google Scholar
  59. 59.
    Dormandy, J.A., Charbonnel, B., Eckland, D.J., et al., Lancet, 2005, vol. 366, pp. 1279–1289.CrossRefPubMedGoogle Scholar
  60. 60.
    Campbell, I.W., Br. J. Diabets Vasc. Dis., 2005, vol. 5, pp. 272–274.CrossRefGoogle Scholar
  61. 61.
    Mazzone, T., Meyer, P.M., Feinstein, S.B., et al., J. Am. Med. Ass., 2006, vol. 296, pp. 2572–2581.CrossRefGoogle Scholar
  62. 62.
    Goldberg, R.B., Kendall, D.M., Deeg, M.A., et al., Diabetes Care, 2005, vol. 28, pp. 1547–1554.CrossRefPubMedGoogle Scholar
  63. 63.
  64. 64.
    Henry, R.R., Lincoff, A.M., Mudaliar, S., Rabbia, M., Chognot, C., and Herz, M., Lancet, 2009, vol. 374, pp. 126–135.CrossRefPubMedGoogle Scholar
  65. 65.
  66. 66.
    Ishibashi, S., Yamashita, S., Arai, H., Araki, E., Yokote, K., et al., Atherosclerosis, 2016, vol. 249, pp. 36–43.CrossRefPubMedGoogle Scholar
  67. 67.
    Arai, H., Yamashita, S., and Yokote, K., Atherosclerosis, 2017, vol. 261, pp. 144–152.CrossRefPubMedGoogle Scholar
  68. 68.
    Camejo, G., Atherosclerosis, 2017, vol. 261, pp. 163–164.CrossRefPubMedGoogle Scholar
  69. 69.
  70. 70.
  71. 71.
    Dunn, F.L., Higgins, L.S., Fredrickson, J., and DePaoli, A.M., J. Diabetes Complicat., 2011, vol. 25, pp. 151–158.CrossRefPubMedGoogle Scholar
  72. 72.
  73. 73.
  74. 74.
  75. 75.
  76. 76.
  77. 77.
  78. 78.
    Fedorova, L.V., Sodhi, K., Gatto-Weis, C., Puri, N., et al., PLoS One, 2013, vol. 8. e64436.CrossRefPubMedPubMedCentralGoogle Scholar
  79. 79.
    Goto, T., Nakayama, G.T., Yamanaka, M., Takata, M., et al., Exp. Clin. Endocr. Diab., 2015, vol. 123, pp. 492–499.CrossRefGoogle Scholar
  80. 80.
  81. 81.
    Cariou, B., Zair, Y., Staels, B., and Bruckert, E., Diabetes Care, 2011, vol. 34, pp. 2008–2014.CrossRefPubMedPubMedCentralGoogle Scholar
  82. 82.
    Ratziu, V., Stephen, A. Harrison, S.A., Francque, S., Bedossa, P., et al., Gastroenterology, 2016, vol. 150, pp. 1147–1159.CrossRefGoogle Scholar
  83. 83.
  84. 84.
  85. 85.
    Zhang, L.H., Kamanna, V.S., Ganji, S.H., Xiong, X.M., and Kashyap, M.L., J. Lipid Res., 2012, vol. 53, pp. 941–950.CrossRefPubMedPubMedCentralGoogle Scholar
  86. 86.
    Morgan, J.M., Capuzzi, D.M., Baksh, R.I., Intenzo, C., Carey, C.M., Reese, D., et al., Am. J. Cardiol., 2003, vol. 91, pp. 1432–1436.CrossRefPubMedGoogle Scholar
  87. 87.
    Nicholls, S.J., Cleve. Clin. J. Med., 2012, vol. 79, pp. 38–43.CrossRefPubMedGoogle Scholar
  88. 88.
    Lavigne, P.M. and Karas, R.H., J. Am. Coll. Cardiol., 2013, vol. 61, pp. 440–446.CrossRefPubMedGoogle Scholar
  89. 89.
    Bays, H.E., Ballantyne, C.M., Kastelein, J.J., Isaacsohn, J.L., Braeckman, R.A., and Soni, P.N., Am. J. Cardiol., 2011, vol. 108, pp. 682–690.CrossRefPubMedGoogle Scholar
  90. 90.
    Bäck, M., Future Sci. OA, 2017, vol. 3, no. 4, FSO236. doi 10.4155/fsoa-2017-0067CrossRefPubMedPubMedCentralGoogle Scholar
  91. 91.
    Arsenault, B.J., Boekholdt, S.M., Tardif, J.C., and Kastelein, J.J., Eur. Heart J., 2012, vol. 33, pp. 1548–1550.CrossRefPubMedGoogle Scholar
  92. 92.
    Otocka-Kmiecik, A., Mikhailidis, D.P., Nicholls, S.J., Davidson, M., Rysz, J., and Banach, M., Prog. Lipid. Res., 2012, vol. 51, pp. 314–324.CrossRefPubMedGoogle Scholar
  93. 93.
    Paneni, F., Cosentino, F., Marrara, F., Palano, F., Capretti, G., Gregori, M., et al., Int. J. Cardiol., 2012, vol. 158, pp. 158–160.CrossRefPubMedGoogle Scholar
  94. 94.
    Wadham, C., Albanese, N., Roberts, J., Wang, L., Bagley, C.J., et al., Circulation, 2004, vol. 109, pp. 2116–2122.CrossRefPubMedGoogle Scholar
  95. 95.
    Hafiane, A., Jabor, B., Ruel, I., Ling, J., and Genest, J., Am. J. Cardiol., 2014, vol. 113, pp. 249–255.CrossRefPubMedGoogle Scholar
  96. 96.
    Ertek, S., Curr. Vasc. Pharmacol., 2017 [Epub ahead of print]. doi 10.2174/1570161115666171116164612Google Scholar
  97. 97.
    Burke, A.C., Dron, J.S., Hegele, R.A., and Huff, M.W., Annu. Rev. Pharmacol. Toxicol., 2017, vol. 57, pp. 223–244.CrossRefPubMedGoogle Scholar
  98. 98.
    Lagace, T.A., Curr. Opin. Lipidol., 2014, vol. 25, pp. 387–393.CrossRefPubMedPubMedCentralGoogle Scholar
  99. 99.
    Abifadel, M., Rabès, J.P., Boileau, C., and Varret, M., Ann. Endocrinol. (Paris), 2007, vol. 68, pp. 138–146.CrossRefGoogle Scholar
  100. 100.
    Abifadel, M., Varret, M., Rabes, J.P., et al., Nat. Genet., 2003, vol. 34, pp. 154–156.CrossRefPubMedGoogle Scholar
  101. 101.
    Kukharchuk, V.V. and Bazhan, S.S., Ateroskleroz i Dislipidemii, 2013, no. 2, pp. 19–26.Google Scholar
  102. 102.
    Dietschy, J.M., Turley, S.D., and Spady, D.K., J. Lipid Res., 1993, vol. 34, pp. 1637–1659.PubMedGoogle Scholar
  103. 103.
    Surdo, P.L., Bottomley, M., Calzetta, A., Settembre, E.C., et al., EMBO Rep., 2011, vol. 12, pp. 1300–1305.CrossRefPubMedPubMedCentralGoogle Scholar
  104. 104.
    Weinreich, M. and Frishman, W.H., Cardiol. Rev., 2014, vol. 22, no. 3, pp. 140–146.CrossRefPubMedGoogle Scholar
  105. 105.
    Robinson, J.G., Farnier, M., Krempf, M., Bergeron, G., et al., New Engl. J. Med., 2015, vol. 372, pp. 1489–1499.CrossRefPubMedGoogle Scholar
  106. 106.
    Roth, E.M., McKenney, J.M., Hanotin, C., Asset, G., and Stein, E.A., New Engl. J. Med., 2012, vol. 367, pp. 1891–1900.CrossRefPubMedGoogle Scholar
  107. 107.
    Puri, R., Nissen, S.E., Somaratne, R., Cho, L., Kastelein, J.J.P., et al., Am. Heart J., 2016, vol. 176, pp. 83–92.CrossRefPubMedGoogle Scholar
  108. 108.
    Nanjee, M.N., Cooke, C.J., Garvin, R., et al., J. Lipid Res., 2001, vol. 42, pp. 1586–1593.PubMedGoogle Scholar
  109. 109.
    Pownall, H.J. and Ehnholm, C., Curr. Opin. Lipidol., 2005, vol. 16, pp. 265–268.CrossRefPubMedGoogle Scholar
  110. 110.
    Markin, S.S., Olbinskaya, L.I., and Torkhovskaya, T.I., Fosfolipidnaya terapiya ateroskleroza (Phospholipid Therapy of Atherosclerosis), Moscow, 2016.Google Scholar
  111. 111.
    Kudinov, V.A., Ipatova, O.M., Fedorov, I.G., Totolyan, G.G., et al., Biomed. Khim., 2016, vol. 62, pp. 704–707. doi 10.18097/pbmc20166206704CrossRefPubMedGoogle Scholar
  112. 112.
    Wójcicka, G., Jamroz-Wiśniewska, A., Horoszewicz, K., and Bełtowskil, J., Postepy Hig. Med. Dosw. (online), 2007, vol. 61, pp. 736–759.Google Scholar
  113. 113.
    Hong, C. and Tontonoz, P., Nat. Rev. Drug. Discov., 2014, vol. 13, pp. 433–444.CrossRefPubMedGoogle Scholar
  114. 114.
    Shih, D.M., Shaposhnik, Z., Meng, Y., Rosales, M., Wang, X., Wu, J., et al., FASEB J., 2013, vol. 27, no. 9, pp. 3805–3817.CrossRefPubMedPubMedCentralGoogle Scholar
  115. 115.
    Wang, D.Q., Tazuma, S., Cohen, D.E., and Carey, M.C., Am. J. Physiol. Gastrointest. Liver Physiol., 2003, vol. 285, pp. G494–G502.CrossRefPubMedGoogle Scholar
  116. 116.
    Camilleri, M. and Gores, G.J., Am. J. Physiol. Gastrointest. Liver Physiol., 2015, vol. 309, pp. G209–G215.CrossRefPubMedPubMedCentralGoogle Scholar
  117. 117.
    Sato, H., Macchiarulo, A., Thomas, C., Gioiello, A., Une, M., Hofmann, A.F., Saladin, R., et al., J. Med. Chem., 2008, vol. 51, pp. 1831–1841.CrossRefPubMedGoogle Scholar
  118. 118.
    Nicholls, S.J., Gordon, A., and Johanson, J., Cardiovasc. Drugs Ther., 2012, vol. 26, pp. 181–187.CrossRefPubMedGoogle Scholar
  119. 119.
    Uehara, Y., Ando, S., Yahiro, E., Oniki, K., Ayaori,M., Abe, S., et al., J. Am. Heart. Assoc., 2013, vol. 2. e000048. doi 10.1161/JAHA.113.000048CrossRefPubMedPubMedCentralGoogle Scholar
  120. 120.
    Miyazaki, A., Sakuma, S., Morikawa, W., Takiue, T., Miake, F., and Terano, T., Arterioscler. Thromb. Vasc. Biol., 1995, vol. 15, pp. 1882–1888.CrossRefPubMedGoogle Scholar
  121. 121.
    Ibanez, B., Vilahur, G., Cimmino, G., Speidl, W.S., Pinero, A., Choi, B.G., et al., J. Am. Coll. Cardiol., 2008, vol. 51, pp. 1104–1109.CrossRefPubMedGoogle Scholar
  122. 122.
    Cimmino, G., Ibanez, B., Vilahur, G., Speidl, W.S., Fuster, V., Badimon, L., et al., J. Cell Mol. Med., 2009, vol. 13, pp. 3226–3235.CrossRefPubMedGoogle Scholar
  123. 123.
    Navab, M., Hough, G., Buga, G.M., Su, F., Wagner, A.C., Meriwether, D., Chattopadhyay, A., et al., J. Lipid Res., 2013, vol. 54, pp. 3403–3418.CrossRefPubMedPubMedCentralGoogle Scholar
  124. 124.
    Navab, M., Shechter, I., Anantharamaiah, G.M., Reddy, S.T., et al., Arterioscler. Thromb. Vasc. Biol., 2010, vol. 30, pp. 164–168.CrossRefPubMedGoogle Scholar
  125. 125.
    Chattopadhyay, A., Navab, M., Hough, G., Gao, F., Meriwether, D., Grijalva, V., et al., J. Lipid Res., 2013, vol. 54, pp. 995–1010.CrossRefPubMedPubMedCentralGoogle Scholar
  126. 126.
    Lamon-Fava, S., Diffenderfer, M.R., Barrett, P.H., et al., Arterioscler. Thromb. Vasc. Biol., 2008, vol. 28, pp. 1672–1678.CrossRefPubMedPubMedCentralGoogle Scholar
  127. 127.
    Sviridov, D.D., Karagodin, V.P., Orekhova, V.A., Melnichenko, A.A., and Orekhov, A.N., Patogenez, 2012, vol. 10, no. 2, pp. 4–18.Google Scholar
  128. 128.
    Picaud, S., Well, C., and Felletar, I., Proc. Natl. Acad. Sci. USA, 2013, vol. 110, pp. 19754–19759.CrossRefPubMedPubMedCentralGoogle Scholar
  129. 129.
    Bailey, D., Jahagirdar, R., Gordon, A., Hafiane, A., et al., J. Am. Coll. Cardiol., 2010, vol. 55, pp. 2580–2589.CrossRefPubMedGoogle Scholar
  130. 130.
    Gilham, D., Wasiak, S., and Tsujikawa, L.M., Atherosclerosis, 2016, vol. 247, pp. 48–57.CrossRefPubMedGoogle Scholar
  131. 131.
  132. 132.
    Tardif, J.C., Gregoire, J., L’Allier, P.L., Ibrahim, R., Lesperance, J., Heinonen, T.M., et al., J. Am. Med. Ass., 2007, vol. 297, pp. 1675–1682.CrossRefGoogle Scholar
  133. 133.
    Kingwell, B.A. and Chapman, M.J., Circulation, 2013, vol. 128, pp. 1112–1121.CrossRefPubMedGoogle Scholar
  134. 134.
    Badimon, J.J., Badimon, L., and Fuster, V., J. Clin. Invest., 1990, vol. 85, pp. 1234–1241.CrossRefPubMedPubMedCentralGoogle Scholar
  135. 135.
    Diditchenko, S., Gille, A., Pragst, I., et al., Arteriosler. Thromb. Vasc. Biol., 2013, vol. 33, pp. 2202–2211.CrossRefGoogle Scholar
  136. 136.
  137. 137.
    Tardif, J.C., Ballantyne, C.M., Barter, P., Dasseux, J.L., Fayad, Z.A., Guertin, M.C., et al., Eur. Heart J., 2014, vol. 35, pp. 3277–3286.CrossRefPubMedPubMedCentralGoogle Scholar
  138. 138.
    Keyserling, C.H., Hunt, T.L., Klepp, H.M., Scott, R.A., et al., Circulation, 2011, vol. 124. A15525Google Scholar
  139. 139.
    Tardy, C., Goffinet, M., Boubekeur, N., Ackermann, R., Sy, G., Bluteau, A., et al., Atherosclerosis, 2014, vol. 232, pp. 110–118.CrossRefPubMedGoogle Scholar
  140. 140.
    Kataoka, Y., Andrews, J., Duong, M., et al., Cardiovasc. Diagn. Ther., 2017, vol. 7, pp. 252–263.CrossRefPubMedPubMedCentralGoogle Scholar
  141. 141.
    Speidl, W.S., Cimmino, G., Ibanez, B., et al., Eur. Heart. J., 2010, vol. 31, pp. 2049–2057.CrossRefPubMedGoogle Scholar
  142. 142.
    Nissen, S.E., Tsunoda, T., Tuzcu, E.M., Schoenhagen, P., Cooper, C.J., Yasin, M., et al., J. Am. Med. Ass., 2003, vol. 290, pp. 2292–2300.CrossRefGoogle Scholar
  143. 143.
    Ibanez, B., Giannarelli, C., Cimmino, G., et al., Atherosclerosis, 2012, vol. 220, pp. 72–77.CrossRefPubMedGoogle Scholar
  144. 144.
    Kastelein, J.J., Ross, C.J., and Hayden, M.R., Hum. Gene Ther., 2013, vol. 24, no. 5, pp. 472–478.CrossRefPubMedGoogle Scholar
  145. 145.
    Gaudet, B., Méthot, J., Déry, S., et al., Gene Therapy, 2013, vol. 20, no. 4, pp. 361–369.CrossRefPubMedGoogle Scholar
  146. 146.
  147. 147.
    Hafiane, A. and Genest, J., Cholesterol, 2013, vol. 2013, article ID 891403. doi 10.1155/2013/891403Google Scholar
  148. 148.
    Marquart, J., Allen, R.M., Ory, D.S., and Baldán, A., Proc. Natl. Acad. Sci. USA, 2010, vol. 107, pp. 12228–12232.CrossRefPubMedPubMedCentralGoogle Scholar
  149. 149.
    Kuai, R., Li, D., Chen, Y.E., Moon, J.J., and Schwendeman, A., ACS Nano, 2016, vol. 10, no. 3, pp. 3015–3041.CrossRefPubMedPubMedCentralGoogle Scholar
  150. 150.
  151. 151.
    Wong, E. and Goldberg, T., P&T, 2014, vol. 39, no. 2, pp. 119–122.Google Scholar
  152. 152.
  153. 153.
  154. 154.
  155. 155.
    Crooke, R.M., Baker, B.F., and Wedel, M., Antisense Drug Technology: Principles, Strategies, and Applications, Crooke, S.T., Ed., 2nd ed., Boca Raton, FL: CRC Press, 2007, pp. 601–639.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • V. A. Kudinov
    • 1
  • T. S. Zakharova
    • 1
  • T. I. Torkhovskaya
    • 1
  • O. M. Ipatova
    • 1
  • A. I. Archakov
    • 1
  1. 1.Institute of Biomedical Chemistry (IBMC)MoscowRussia

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