Formation and participation of nano-amyloids in pathogenesis of Alzheimer’s disease and other amyloidogenic diseases



Studies of neurodegenerative disorders attract much attention of the world scientific community due to increasing dissemination of Alzheimer’s disease. The reason for such pathologies consists in transition of a “healthy” molecule or peptide from its native conformation into a very stable “pathological” form. During this process, molecules existing in the “pathological” conformation aggregate and form amyloid fibrils that can undergo an uncontrolled increase. Novel knowledge is required on sporadic forms of Alzheimer’s disease, on the nature of triggering mechanisms of the conformational transitions of beta-amyloid fragments from normally functioning proteins into new structure, nano-beta-amyloids, that escape of neuronal and whole-body control resulted in the loss of neurons. This review summarized results of studies on the formation of amyloid fibrils and their role in pathogenesis of amyloid diseases.

Key words

Alzheimer’s disease beta-amyloid amyloid fibril structure kinetics of fibril formation 


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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Russian Gerontological Research Clinical CenterRussian Ministry of Health CareMoscowRussia
  2. 2.Institute of Protein ResearchRussian Academy of SciencesPushchino, Moscow RegionRussia
  3. 3.Institute of Biological InstrumentationRussian Academy of SciencesPushchino, Moscow RegionRussia

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