Neurochemical Journal

, Volume 12, Issue 1, pp 41–47 | Cite as

The Involvement of Agmatine in Individual Pain Sensitivity

  • L. A. Mnatsakanyan
  • T. V. Balashova
  • A. A. Sosin
  • V. B. Shumatov
  • I. V. Dyuizen
Experimental Articles
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Abstract

Distribution of agmatinase (AGM), an enzyme of agmatine metabolism, was studied in the spinal cord and dorsal root ganglia of rats with different levels of initial thermal pain sensitivity under normal conditions and during the development of inflammatory pain using immunohistochemistry. The initial type of pain threshold affects the specific pain response of an animal to pain so that the rats with a higher threshold exhibit a less-expressed behavioral pain response. We found a specific distribution and time course of activity of AGM in the brain regions of animals with different nociceptive thresholds. The animals with a lower threshold had a higher number of AGM-immunoreactive neurons in the ganglia and a lower density of fibers and neurons in the dorsal roots of the spinal cord compared to the animals with a higher threshold. The development of tonic pain was associated with differently directed changes of AGM activity in the studied structures and depended on the threshold of nociception. Our data suggest that the endogenous system of agmatine metabolism may be involved in the initial threshold of nociception, as well as in organization of the behavioral response to pain.

Keywords

pain pain threshold agmatine spinal cord dorsal root ganglia 

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References

  1. 1.
    Tabor, C.W. and Tabor, H., Annu. Rev. Biochem., 1984, vol. 53, pp. 749–790.CrossRefPubMedGoogle Scholar
  2. 2.
    Petroff, O.A., Neuroscientist, 2002, vol. 8, no. 6, pp. 562–573.CrossRefPubMedGoogle Scholar
  3. 3.
    Reis, D.J. and Regunathan, S., Trends Pharmacol. Sci., 2000, vol. 21, no. 5, pp. 187–193.CrossRefPubMedGoogle Scholar
  4. 4.
    Halaris, A. and Piletz, J., CNS Drugs, 2007, vol. 21, pp. 885–900.CrossRefPubMedGoogle Scholar
  5. 5.
    Gawali, N.B., Bulani, V.D., Chowdhury, A.A., Deshpande, P.S., Nagmoti, D.M., and Juvekar, A.R., Pharmacol. Biochem. Behav., 2016, vol. 149, pp. 1–8.CrossRefPubMedGoogle Scholar
  6. 6.
    Moretti, M., Neis, V.B., Matheus, F.C., Cunha, M.P., Rosa, P.B., Ribeiro, C.M., Rodrigues, A.L., and Prediger, R.D., Neurotox. Res., 2015, vol. 28, pp. 222–231.CrossRefPubMedGoogle Scholar
  7. 7.
    Sahin, C., Albayrak, O., Akdeniz, T.F., Akbulut, Z., Yanikkaya, DemirelG., and Aricioglu, F., Basic Clin. Pharmacol. Toxicol., 2016, vol. 119, pp. 367–375.CrossRefPubMedGoogle Scholar
  8. 8.
    Xu, H., Ou, F., Wang, P., Naren, M., Tu, D., and Zheng, R., Exp. Ther. Med., 2014, vol. 8, pp. 73–78.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Kitto, K.F. and Fairbanks, C.A., Eur. J. Pharmacol., 2006, vol. 536, pp. 133–137.CrossRefPubMedGoogle Scholar
  10. 10.
    Santos, A.R., Gadotti, V.M., Oliveira, G.L., Tibola, D., Paszcuk, A.F., Neto, A., Spindola, H.M., Souza, M.M., Rodrigues, A.L., and Calixto, J.B., Neuropharmacology, 2005, vol. 48, pp. 1021–1034.CrossRefPubMedGoogle Scholar
  11. 11.
    Courteix, C., Privat, A.-M., Pelissier, T., Hernandez, A., Eschalier, A., and Fialip, J., J. Pharmacol. Exp. Ther., 2007, vol. 322, no. 3, pp. 1237–1245.CrossRefPubMedGoogle Scholar
  12. 12.
    Fairbanks, C.A., Schreiber, K.L., Brewer, K., Yu, C.G., Stone, L.S., Kitto, K.F., Nguyen, H.O., Grocholski, B.M., Shoeman, D.W., Kehl, L.J., Regunathan, S., Reis, D.J., Yezierski, R.P., and Wilcox, G.L., Proc. Natl. Acad. Sci. U.S.A., 2000, vol. 97, no. 19, pp. 10584–10589.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Gabotti, V.M., Tibola, D., Paszcuk, A.F., Rodrigues, A.L., Calixto, J.B., and Santos, A.R., Brain Res., 2006, vol. 1093, no. 1, pp. 116–122.CrossRefGoogle Scholar
  14. 14.
    Gonzalez, S., NIDA Notes, 2001, vol. 16, no. 3, pp. 10–11.Google Scholar
  15. 15.
    Uzbay, T.I., Neurosci. Biobehav. Rev., 2012, vol. 36, pp. 502–519.CrossRefPubMedGoogle Scholar
  16. 16.
    Fairbanks, C.A., Schreiber, K.L., Brewer, K.L., Yu, C.G., Stone, L.S., Kitto, K.F., Nguyen, H.O., Grocholski, B.M., Shoeman, D.W., Kehl, L.J., Regunathan, S., Reis, D.J., Yezierski, R.P., and Wilcox, G.L., Proc. Natl. Acad. Sci. U.S.A., 2000, vol. 97, pp. 10584–10589.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Janicki, P.K. and Parris, W., Curr. Pain Headache Reports, 1997, vol. 1, pp. 271–277.Google Scholar
  18. 18.
    Fillingim, R.B., Curr. Rheumatol. Rep., 2005, vol. 7, pp. 342–347.CrossRefPubMedGoogle Scholar
  19. 19.
    Nielsen, C.S., Staud, R., and Price, D.D., J. Pain, 2009, vol. 10, pp. 231–237.CrossRefPubMedGoogle Scholar
  20. 20.
    Bereiter, D.A., Cioffi, J.L., and Bereiter, D.F., Arch. Oral. Biol., 2005, vol. 50, pp. 971–979.CrossRefPubMedGoogle Scholar
  21. 21.
    Berkley, K.J., Behav. Brain Sci., 1997, vol. 20, no. 3, pp. 371–380.PubMedGoogle Scholar
  22. 22.
    Craft, R.M., Pain, 2007, vol. 132, no. 1 Suppl., pp. S3–S12.CrossRefPubMedGoogle Scholar
  23. 23.
    Fillingim, R.B., King, C.D., Ribeiro-DaSilva, M.C., Rahim-Williams, B., and Riley, J.L. 3rd, J. Pain, 2009, vol. 10, no. 4, pp. 447–485.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Wiesenfeld-Hallin, Z., Gender Medicine, 2005, vol. 2, pp. 137–145.CrossRefPubMedGoogle Scholar
  25. 25.
    Dyuizen, I.V., Balashova, T.V., Lamash, N.E., Mnatsakanyan, L.A., Sosin, A.A., Bykov, A.O., and Shumatov, V.B., Tikhookeansk. Med. Zhurn., 2014, no. 2, pp. 43–47.Google Scholar
  26. 26.
    Sosin, A.A., Balashova, T.V., Dyuizen, I.V., Lamash, N.E., Mnatsakanyan, L.A., Bykov, A.O., and Shumatov, V.B., Ross. Zhurn. Boli, 2015, no. 2, pp. 12–15.Google Scholar
  27. 27.
    Li, G., Regunathan, S., and Reis, D.J., Ann. NY Acad. Sci., 1995, vol. 763, pp. 325–329.CrossRefPubMedGoogle Scholar
  28. 28.
    Demady, D.R., Jianmongkol, S., Vuletich, J.L., Bender, A.T., and Osawa, Y., Mol. Pharmacol., 2001, vol. 59, pp. 24–29.CrossRefPubMedGoogle Scholar
  29. 29.
    Regunathan, S. and Piletz, J., Ann. NY Acad. Sci., 2003, vol. 1009, pp. 24–29.CrossRefGoogle Scholar
  30. 30.
    Askalany, A., Yamakura, T., Petrenko, A., Kohno, T., Sakimura, K., and Baba, H., Neurosci. Res., 2005, vol. 52, pp. 387–392.CrossRefPubMedGoogle Scholar
  31. 31.
    Kolesnikov, Y., Jain, S., and Pasternak, G.W., Eur. J. Pharmacol., 1996, vol. 296, pp. 17–22.CrossRefPubMedGoogle Scholar
  32. 32.
    Regunathan, S., AAPS J., 2006, vol. 8, no. 5, pp. 479–484.CrossRefGoogle Scholar
  33. 33.
    Aricioglu-Kartal, F. and Uzbay, I.T., Life Sci., 1997, vol. 61, pp. 1775–1781.CrossRefPubMedGoogle Scholar
  34. 34.
    Fairbanks, C.A., Schreiber, K.L., Brewer, K.L., Yu, C.G., Stone, L.S., Kitto, K.F., Nguyen, H.O., Grocholski, B.M., Shoeman, D.W., Kehl, L.J., Regunathan, S., Reis, D.J., Yezierski, R.P., and Wilcox, G.L., Proc. Natl. Acad. Sci. U.S.A., 2000, vol. 97, no. 19, pp. 10584–10589.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Regunathan, S., AAPS J., 2006, vol. 8, no. 5, pp. 479–484.CrossRefGoogle Scholar
  36. 36.
    Uzbay, T.I., Neurosci. Biobehav. Rev., 2012, vol. 36, no. 1, pp. 502–519.CrossRefPubMedGoogle Scholar
  37. 37.
    Reis, D.J. and Regunathan, S., Ann. NY Acad. Sci., 1999, vol. 881, pp. 65–80.CrossRefPubMedGoogle Scholar
  38. 38.
    Skachkov, S.N., Antonov, S.M., and Iton, M.J., Biol. Membr., 2016, vol. 33, no. 1, pp. 3–31.Google Scholar
  39. 39.
    Braissant, O., Gotoh, T., Loup, M., Mori, M., and Bachmann, C., Mol. Brain Res., 2001, vol. 91, pp. 189–195.CrossRefPubMedGoogle Scholar
  40. 40.
    Manzhulo, I.V. and Dyuizen, I.V., Neurochem. J., 2015, vol. 9, no. 3, pp. 227–231.CrossRefGoogle Scholar
  41. 41.
    Uzbay, T., Curr. Med. Chem., 2012, vol. 19, pp. 5116–5121.CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • L. A. Mnatsakanyan
    • 1
    • 4
  • T. V. Balashova
    • 1
  • A. A. Sosin
    • 1
  • V. B. Shumatov
    • 1
  • I. V. Dyuizen
    • 2
    • 3
  1. 1.Pacific State Medical UniversityVladivostokRussia
  2. 2.National Scientific Center of Marine Biology, Far East BranchRussian Academy of SciencesVladivostokRussia
  3. 3.School of BiomedicineFar East Federal UniversityVladivostokRussia
  4. 4.VladivostokRussia

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