Specific monoamine exchange in the brains of young and aged male rats with hypothyroidism
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We analyzed monoamine exchange in different brain structures of young (2-month-old) and aged (22–24 month-old) male rats under conditions of thyroid hormone (TH) deficit or 14-day-long intraperitoneal (T3) administration of triiodothyronine at a dose of 70 μg/kg. The contents of monoamines and their metabolites were assayed using HPLC with an electrochemical detector. In the brain structures directly related to animal behavior a TH deficit resulted in changes in monoamines, which depended on the ages of the rats. During experimental hypothyroidism, the most substantial changes in the contents and turnover of norepinephrine, dopamine, and serotonin were observed in the brains of young male rats. In aged animals, a TH deficit increased impairments in neurotransmitter exchange. Substitutive T3 administration did not improve monoamine exchange in the brain structures of young male rats with hypothyroidism. In the aged rats with hypothyroidism, T3 administration restored monoamine exchange only in the hippocampus but not in other brain structures.
Key wordsthyroid hormones HPLC monoamines age aging
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- 1.Agadzhanyan, N.A., Tel’, L.Z., and Tsirkin, V.I., in Osnovy fiziologii cheloveka (Basic Human Physiology), Moscow: Med. kniga, 2003.Google Scholar
- 2.Eshchenko, N.D., Biokhimiya psikhicheskikh i nervnykh boleznei (Biochemistry of Psychic and Neurological Diseases), St. Petersburg: Sankt-Peterburgskii universitet, 2004.Google Scholar
- 3.Kirshenblat, Ya.D., in Praktikum po endokrinologii (Handbook of Endocrinology), Moscow: Vysshaya shkola, 1969.Google Scholar
- 4.Miroshnichenko, I.I., Kudrin, V.S., and Raevskii, K.S., Farmakol. Toksikol., 1988, no. 2, pp. 26–29.Google Scholar
- 6.Sapronov, N.S. and Fedotova, Yu.O., in Osnovy Neiroendokrinologii (Basic Neuroendocrinology), St. Petersburg: ELBI, 2005, pp. 32–83.Google Scholar
- 7.Sapronov, N.S. and Fedotova, Yu.O., in Gormony gipotalamo-gipofizarno-tireoidnoi sistemy i mozg (Hormones of the Hypothalamus-Pituitary-Thyroid System and the Brain), St. Petersburg: Lan’, 2002.Google Scholar
- 8.Alkemade, A., Visser, T.J., and Fliers, E., Curr. Opin. Endicrinol. Diabets Obes., 2008, vol. 15, pp. 453–458.Google Scholar
- 13.Olie, J.P., Costa, E., Silva, J., and Macher, J.P., Neuroplasticity: a New Approach to the Pathophysiology of Depression, London (UK): Science Press, 2004.Google Scholar