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Neurochemical Journal

, Volume 3, Issue 1, pp 44–48 | Cite as

Analysis and prediction of ATP concentration in the animal brain under hypoxic conditions

  • A. N. Moshkova
  • E. M. Khvatova
  • I. A. Rusakova
Experimental Articles
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Abstract

We performed a mathematical analysis of the dependence of the final concentration of ATP in the brain tissue of animals on the activity of oxidative mitochondrial enzymes. We constructed a mathematical model that approximates this relationship under different conditions of the body’s vital activity. The model proposed helps to calculate and predict the energetic state of the brain during mitochondrial dysfunction of the respiratory chain induced by hypoxias of different severities.

Key words

adenosine-5′-triphosphate oxidative mitochondrial enzymes hypoxia brain 

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Copyright information

© MAIK Nauka 2009

Authors and Affiliations

  • A. N. Moshkova
    • 1
    • 2
    • 3
  • E. M. Khvatova
    • 2
    • 3
  • I. A. Rusakova
    • 2
    • 3
  1. 1.Nizhni NovgorodRussia
  2. 2.State Technical UniversityNizhni NovgorodRussia
  3. 3.State Medical AcademyNizhni NovgorodRussia

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