Neurochemical Journal

, Volume 2, Issue 3, pp 202–208 | Cite as

Carnosine protects cells from oxidative stress induced by hyperhomocysteinemia

  • A. V. Makhro
  • A. P. Mashkina
  • O. A. Solenaya
  • O. A. Trunova
  • O. V. Tyulina
  • E. R. Bulygina
  • A. A. Boldyrev
Experimental Articles

Abstract

Prenatal hyperhomocysteinemia induced in rats by overloading of dietary methionine (1 g/kg body mass daily) results in systemic disordering in progeny related to an increase in the excitotoxic feature of NMDA-receptors in cerebellar neurons and memory suppression. Administration of carnosine (100 mg/kg body mass daily) in the diet of pregnant rats with hyperhomocysteinemia prevents both cognitive function in pups and protects cerebellar neurons from oxidative stress. The effect of carnosine is accompanied by with the restoration of superoxide dismutase in rat brain, which is decreased during hyperhomocysteinemia from 2.07 units (control) to 1.54 units.

Key words

prenatal hyperhomocysteinemia carnosine N-methyl-D-aspartate (NMDA) homocysteine homocysteic acid 

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • A. V. Makhro
    • 1
  • A. P. Mashkina
    • 1
    • 2
  • O. A. Solenaya
    • 1
  • O. A. Trunova
    • 2
  • O. V. Tyulina
    • 1
  • E. R. Bulygina
    • 1
  • A. A. Boldyrev
    • 1
    • 2
  1. 1.Department of BiochemistrySchool of Biology and International Biotechnological Center of Lomonosov Moscow State UniversityMoscowRussia
  2. 2.Research Center of Neurology Russian Academy of Medical SciencesMoscowRussia

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