Glyprolines in regulatory tripeptides
- Cite this article as:
- Ashmarin, I.P. Neurochem. J. (2007) 1: 173. doi:10.1134/S1819712407030014
Glyprolines widely occur in structures of regulatory oligopeptides with a wide spectrum of bioactivities. The role of glyprolines is most significant in regulatory tripeptides. They participate in the stabilization of regulatory oligopeptides in organisms and in the generation of a complex new spectra of bioactivities. Gly-Pro-Glu, Gly-Pro-Leu, Leu-Gly-Pro, Gly-Pro-Arg, Ac-Pro-Gly-Pro, and Gly-Pro-Gly-NH2 serve as examples. The glyprolines deserve further systematic comparative studies. The data in this review can be used to guide elaboration of new peptide medicinal drugs, including hybrid peptides.
Key wordsglyprolines regulatory peptides tripeptides Gly-Pro-Glu Gly-Pro-Leu Leu-Gly-Pro Gly-Pro-Arg Ac-Pro-Gly-Pro Gly-Pro-Gly-NH2