Advertisement

Neurochemical Journal

, Volume 1, Issue 2, pp 138–142 | Cite as

The effect of the synthetic neuroprotective dipeptide noopept on glutamate release from rat brain cortex slices

  • K. S. Us
  • P. M. Klodt
  • V. S. Kudrin
  • A. Ya. Sapronova
  • R. U. OstrovskayaEmail author
  • M. V. Ugryumov
  • K. S. Rayevsky
Experimental Articles

Abstract

The level of spontaneous and K+-stimulated release of endogenous glutamate was studied in experiments on slices of brain cortex of Wistar rats. Pronounced spontaneous release of the neuromediator and its increase under conditions of stimulation were registered by high-performance liquid chromatography with electrochemical detection. The effect of the nootropic and neuroprotective dipeptide Noopept (GVS-111) on release of glutamate was investigated. The peptide in concentrations of 10−5 and 10−6 M caused a statistically significant decrease in spontaneous and K+-stimulated glutamate release. This effect could be the basis of the neuroprotective action of the peptide, suggesting that further studies of Noopept as neuroprotector are very promising.

Key words

glutamate release brain cortex slices Noopept neuroprotective properties 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Danysz, W. and Parsons, C.G., Pharmacol. Rev., 1998, vol. 50, pp. 455–474.Google Scholar
  2. 2.
    Siegel, G.J., Basic Neurochemistry, New. York., USA: Raven Press, 1989, pp. 43–46.Google Scholar
  3. 3.
    Benveniste, H., Drejer, J., Schusboe, A., and Diemer, N.H., J. Neurochem., 1984, vol. 43, pp. 1369–1374.PubMedCrossRefGoogle Scholar
  4. 4.
    Nicholls, D.G. and Attwell, D., Trends Pharmacol Sci., 1990, vol. 11, pp. 462–468.PubMedCrossRefGoogle Scholar
  5. 5.
    Nickolson, V.J. and Wolthuis, O.L., Brain Res., 1976, vol. 113, pp. 616–619.PubMedCrossRefGoogle Scholar
  6. 6.
    Gudasheva, T.A., Trofimov, S.S., Ienkina, F.V., et al., Khim.-Farm. Zh., 1985, vol. 11, pp. 1319–1322.Google Scholar
  7. 7.
    Gudasheva, T.A., Voronina, T.A., Ostrovskaya, R.U. et al., Eur. J. Med. Chem., 1996, vol. 31, no. 2, pp. 151–157.CrossRefGoogle Scholar
  8. 8.
    Seredenin, S.B., Voronina, T.A., Ostrovskaya R.U., et al., US Patent 5.439, 930, 1995.Google Scholar
  9. 9.
    Ostrovskaya, R.U., Gudasheva, T.A., Voronina, T.A., and Seredinin, S.B., Exp. and Klin. Farmacol., 2002, vol. 65, no. 5, pp. 66–72.Google Scholar
  10. 10.
    Ostrovskaya, R., Romanova, G.A., Barskov, I.A. et al., Behav. Pharmacol., 1999, vol. 10, pp. 549–563.PubMedCrossRefGoogle Scholar
  11. 11.
    Andreeva, N.A., Stemal’shuk, E.V., Isaev, N.K., et al., Bull. Exp. Biol. Med., 2000, vol. 130, no. 10, pp. 418–421.CrossRefGoogle Scholar
  12. 12.
    Pelsman, A., Ostrovskaya, R.U., Busciglio, J. et al., Int. J. Devel. Neuroscience, 2003, vol. 803, pp. 1–8.Google Scholar
  13. 13.
    Koinig, H., Vornik, V., Rueda, C. et al., Brain Res., 2001, vol. 898, no. 2, pp. 297–302.PubMedCrossRefGoogle Scholar
  14. 14.
    Graham, S., Chen, J., Lan J. et al., J. Pharmacol. Exp. Ther., 1994, vol. 269, pp. 854–859.PubMedGoogle Scholar
  15. 15.
    Meredith, R.M., Mccabe, B.J. et al., Neuroscience, 2004, vol. 126, pp. 249–256.PubMedCrossRefGoogle Scholar
  16. 16.
    Pearson, S.J., Czudek, C., and Mercer, K., J. Neural Transm., 1991, vol. 86, pp. 151–157.CrossRefGoogle Scholar
  17. 17.
    Moroni, F., Corradetti, R., Casamenti, F., et al., Glutamate as a Neurotransmitter, Chiaraand, G.D.L., Gessa, G.L., Eds., New York: Raven Press, 1981, pp. 157–160.Google Scholar
  18. 18.
    Davies, J.A., Johns, L., and Jones, F.A., Pharmacopsychiatry, 2003, vol. 36,Suppl. 1, pp. 84–88.Google Scholar
  19. 19.
    Ostrovskaya, R.U., Mirzoev, T.Kh., Firsova, F.A. et al., Exp. Klin. Farmacol., 2001, vol. 64, no. 2, pp. 11–14.Google Scholar
  20. 20.
    Tarumi et al., Brain Res. Bull., 2000, vol. 51, no. 5, pp. 407–411.PubMedCrossRefGoogle Scholar
  21. 21.
    Curras-Collazo, M.C. and Gillard, E.R., J. Neuroendocrinol., 2003, vol. 15, no. 2, pp. 182–190.PubMedCrossRefGoogle Scholar
  22. 22.
    Bering, B. and Muller, W., Arzheim.-Forsch./Drug Bes., 1985, vol. 35(11), no. 9, pp. 15–19.Google Scholar
  23. 23.
    Rose, C. and Kresse, W., J. Biol. Chem., 2005, vol. 280, no. 22, pp. 20937–20944.PubMedCrossRefGoogle Scholar
  24. 24.
    Solnceva, E.I., Bukanova, Ju.M., Ostrovskaya, R.U. et al., Gen. Pharmacol., 1997, vol. 29, pp. 85–89.Google Scholar
  25. 25.
    Bukanova, Ju., Solnzeva, E., and Skrebitsky, V., Int. J. Neuropsychopharm., 2002, vol. 5, pp. 229–237.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2007

Authors and Affiliations

  • K. S. Us
    • 1
  • P. M. Klodt
    • 1
  • V. S. Kudrin
    • 1
  • A. Ya. Sapronova
    • 2
  • R. U. Ostrovskaya
    • 1
    Email author
  • M. V. Ugryumov
    • 2
  • K. S. Rayevsky
    • 1
  1. 1.Zakusov Research Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia
  2. 2.Kol’tsov Institute of Developmental BiologyRussian Academy of SciencesMoscowRussia

Personalised recommendations