Doklady Biochemistry and Biophysics

, Volume 488, Issue 1, pp 324–326 | Cite as

A New Component in the Mechanism of Regulation of Endogenous Depressive-Like States

  • T. L. Garibova
  • T. A. GudashevaEmail author
  • S. B. Seredenin


It was shown previously that cycloprolylglycine, an endogenous neuropeptide, is a positive AMPA receptor modulator and is able to increase the content of BDNF in neurons. In the present study, using the model of learned helplessness in rats, we showed that cycloprolylglycine at a dose of 1 mg/kg at subchronic intraperitoneal administration reduced the time of animal immobility to passive control values (from 167.6 to 83.6 s) on day 12 of the experiment. This indicates the presence of antidepressant-like activity. The results of the study allow us to consider cycloprolylglycine as a component in the physiological regulation of the depression-like state.



Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • T. L. Garibova
    • 1
  • T. A. Gudasheva
    • 1
    Email author
  • S. B. Seredenin
    • 1
  1. 1.Zakusov Research Institute of Pharmacology, Russian Academy of Medical SciencesMoscowRussia

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