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Doklady Biochemistry and Biophysics

, Volume 488, Issue 1, pp 320–323 | Cite as

Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets

  • Yu. V. SoldatovaEmail author
  • R. A. Kotelnikova
  • A. V. Zhilenkov
  • I. I. Faingold
  • P. A. Troshin
  • M. A. Kozlova
  • D. A. Areshidze
  • S. M. Aldoshin
BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
  • 14 Downloads

Abstract

It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.

Notes

FUNDING

This work was supported by the program of the Presidium of the Russian Academy of Sciences for 2018–2020 “Nanostructures: Physics, Chemistry, Biology, and Basics of Technology” and the State assignment no. 0089-2019-0014. The work on the development of synthesis methods and production of the fullerene derivative were supported by the Russian Science Foundation (project no. 19-13-00411).

COMPLIANCE WITH ETHICAL STANDARDS

Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • Yu. V. Soldatova
    • 1
    • 2
    Email author
  • R. A. Kotelnikova
    • 1
  • A. V. Zhilenkov
    • 1
  • I. I. Faingold
    • 1
    • 2
  • P. A. Troshin
    • 1
    • 3
  • M. A. Kozlova
    • 2
  • D. A. Areshidze
    • 1
    • 2
  • S. M. Aldoshin
    • 1
  1. 1.Institute of Problems of Chemical Physics, Russian Academy of SciencesChernogolovkaRussia
  2. 2.Moscow Region State UniversityMoscowRussia
  3. 3.Skolkovo Institute of Science and TechnologyMoscowRussia

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