Sigma-1 Receptor Agonist Amitriptyline Inhibits Store-Dependent Ca2+ Entry in Macrophages
- 17 Downloads
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist–tricyclic antidepressant amitriptyline—significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest a possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.
COMPLIANCE WITH ETHICAL STANDARDS
Conflict of interests. The authors declare that they have no conflict of interest.
Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
- 3.Rousseaux, C.G. and Greene, S.F., J. Recept. Signal Transduct., 2016, vol. 36, pp. 327–388.Google Scholar
- 8.Milenina, L.S., Krutetskaya, Z.I., Naumova, A.A., Butov, S.N., Krutetskaya, N.I., and Antonov, V.G., Tsitologiya, 2015, vol. 57, no. 7, pp. 518–525.Google Scholar