Doklady Biochemistry and Biophysics

, Volume 483, Issue 1, pp 309–312 | Cite as

Kinetic Instability of Zero Steady State As a Fundamental Cause of Low Efficiency of Chemotherapy of Cancer

  • S. D. Varfolomeev
  • A. V. LukovenkovEmail author
Biochemistry, Biophysics, and Molecular Biology


Using mathematical modeling of the process of cancer treatment by the classical chemotherapy methods and therapy with biological agents, the effect of the kinetic parameters of the model on the final outcome of treatment was studied. It is established that the complete cure (i.e., the formation of a stable steady state with a zero number of cancer cells) cannot be reached by means of only classical chemotherapy.


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© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  1. 1.Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia
  2. 2.Faculty of Chemistry, Faculty of ChemistryMoscow State UniversityMoscowRussia

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