Doklady Biochemistry and Biophysics

, Volume 480, Issue 1, pp 152–154 | Cite as

Epoxygenase Inhibitors Attenuate the Stimulatory Effect of Glutoxim on Na+ Transport in Frog Skin

  • Z. I. KrutetskayaEmail author
  • A. V. Melnitskaya
  • V. G. Antonov
  • A. D. Nozdrachev
Biochemistry, Biophysics, and Molecular Biology


Using voltage-clamp technique, the involvement of epoxygenases in immunomodulatory drug glutoxim regulation of Na+ transport in frog skin was investigated. We have shown for the first time that preincubation of the frog skin with epoxygenase inhibitors econazole or proadifen almost completely inhibits the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of the enzymes and/or products of epoxygenase oxidation pathway of arachidonic acid metabolism in glutoxim effect on Na+ transport in frog skin epithelium.


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Z. I. Krutetskaya
    • 1
    Email author
  • A. V. Melnitskaya
    • 1
  • V. G. Antonov
    • 1
  • A. D. Nozdrachev
    • 1
  1. 1.St. Petersburg State UniversitySt. PetersburgRussia

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