Study of Human Fibrinogen Oxidative Modification using Differential Scanning Calorimetry
For the first time, with the aid of differential scanning calorimetry, the thermal denaturation of fibrinogen under induced oxidation was studied. All fibrinogen structural elements detected by DSC (D region, αC-domain, and E region) are subjected to oxidation. Structural changes in fibrinogen molecule were characterized by the denaturation temperature, denaturation enthalpy, and van’t Hoff enthalpy.
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- 3.Yurina, L.V., Vasilyeva, A.D., Indeykina, M.I., Bugrova, A.E., Bychkova, A.V., Kononikhin, A.S., Nikolaev, E.N., and Rosenfeld, M.A., Free Rad. Research ( in press).Google Scholar