Doklady Biochemistry and Biophysics

, Volume 480, Issue 1, pp 131–134 | Cite as

Influence of Sodium Selenite on the mRNA Expression of the Mammalian Selenocysteine-Containing Protein Genes in Testicle and Prostate Cancer Cells

  • Yu. P. Kuznetsova
  • M. V. GoltyaevEmail author
  • O. S. Gorbacheva
  • S. V. Novoselov
  • E. G. Varlamova
  • E. E. Fesenko
Biochemistry, Biophysics, and Molecular Biology


The sodium selenite concentration that reduces the viability of Du-145 human prostate adenocarcinoma cells and F-9 mouse testicular teratocarcinoma cells was determined. We investigated the effect of sodium selenite on the mRNA expression level of the genes encoding mammalian selenocysteine-containing glutathione peroxidases and thioredoxin reductases (key antioxidant enzymes involved in the regulation of intracellular thiol redox balance), endoplasmic reticulum selenoproteins, and selenoproteins located in the testes and prostate.


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Yu. P. Kuznetsova
    • 1
  • M. V. Goltyaev
    • 2
    Email author
  • O. S. Gorbacheva
    • 3
  • S. V. Novoselov
    • 2
  • E. G. Varlamova
    • 2
  • E. E. Fesenko
    • 2
  1. 1.Voronezh State University of Engineering TechnologyVoronezhRussia
  2. 2.Institute of Cell BiophysicsRussian Academy of SciencesPushchino, Moscow oblastRussia
  3. 3.Institute of Theoretical and Experimental BiophysicsRussian Academy of SciencesPushchino, Moscow oblastRussia

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