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Doklady Biochemistry and Biophysics

, Volume 471, Issue 1, pp 387–389 | Cite as

Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors

  • T. A. Gudasheva
  • V. V. Grigoriev
  • K. N. Koliasnikova
  • V. L. Zamoyski
  • S. B. Seredenin
Biochemistry, Biophysics, and Molecular Biology

Abstract

We have previously shown that neuropeptide cycloprolylglycine (CPG) increases the content of brain-derived neurotrophic factor (BDNF) in the culture of neuronal cells under normal conditions and in pathology. This is the first study to show that CPG at a physiological concentration of 10–6 M significantly enhances the transmembrane AMPA currents in rat cerebellar Purkinje cells. Thus, CPG is a positive endogenous modulator of AMPA receptors. It was assumed that the neuropsychotropic effects of CPG are implemented as a result of BDNF accumulation after the activation of AMPA receptors by this neuropeptide.

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • T. A. Gudasheva
    • 1
  • V. V. Grigoriev
    • 2
  • K. N. Koliasnikova
    • 1
  • V. L. Zamoyski
    • 2
  • S. B. Seredenin
    • 1
  1. 1.Zakusov Research Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia
  2. 2.Institute of Physiologically Active CompoundsRussian Academy of SciencesChernogolovka, Moscow oblastRussia

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