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Doklady Biochemistry and Biophysics

, Volume 464, Issue 1, pp 341–345 | Cite as

Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin

  • L. V. Yanshole
  • V. V. Yanshole
  • O. A. Snytnikova
  • A. Zh. Fursova
  • N. G. Kolosova
  • Yu. P. Tsentalovich
  • R. Z. Sagdeev
Biochemistry, Biophysics and Molecular Biology

Abstract

The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.

Keywords

Cataract Chaperone Activity DOKLADY Biochemistry Cataract Development Mature Cataract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • L. V. Yanshole
    • 1
    • 2
  • V. V. Yanshole
    • 1
    • 2
  • O. A. Snytnikova
    • 1
  • A. Zh. Fursova
    • 3
  • N. G. Kolosova
    • 4
  • Yu. P. Tsentalovich
    • 1
    • 2
  • R. Z. Sagdeev
    • 1
    • 2
  1. 1.International Tomography Center of the Siberian Branch of Russian Academy of the SciencesNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia
  3. 3.Novosibirsk State Regional Clinical HospitalNovosibirskRussia
  4. 4.Institute of Cytology and Genetics of the Siberian Branch of Russian Academy of the SciencesNovosibirskRussia

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