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Russian Journal of Organic Chemistry

, Volume 54, Issue 10, pp 1548–1552 | Cite as

Synthesis of an Acyclic Precursor to Epothilone D Analog. Aldol Condensation of (1R)-1-(1,3-Dithiolan-2-yl)-1-(methoxymethoxy)- 2,2-dimethylpentan-3-one with C6‒C21 and C6‒C9 Aldehyde Segments

  • R. F. ValeevEmail author
  • G. R. Sunagatullina
  • V. V. Loza
  • M. S. Miftakhov
Article
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Abstract

The synthesis of acyclic precursors to epothilone D analogs has been explored. Optimal conditions have been found for enolization of (1R)-1-(1,3-dithiolan-2-yl)-1-(methoxymethoxy)-2,2-dimethylpentan-3-one and its aldol condensation with C6‒C21 and C6‒C9 aldehydes.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • R. F. Valeev
    • 1
    Email author
  • G. R. Sunagatullina
    • 1
  • V. V. Loza
    • 1
  • M. S. Miftakhov
    • 1
  1. 1.Ufa Institute of Chemistry, Ufa Federal Research CenterRussian Academy of SciencesUfa, BashkortostanRussia

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