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Russian Journal of Organic Chemistry

, Volume 54, Issue 10, pp 1435–1445 | Cite as

Multicomponent Synthesis of 4-Alkyl(Aryl, Hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)- 3,6-diamino-5-cyanothieno[2,3-b]pyridines

  • I. V. Dyachenko
  • V. D. Dyachenko
  • P. V. Dorovatovskii
  • V. N. Khrustalev
  • V. G. Nenajdenko
Article
  • 28 Downloads

Abstract

The condensation of malononitrile with hydrogen sulfide and aldehydes in the presence of triethylamine in ethanol at room temperature afforded 4-alkyl(aryl, hetaryl)-2,6-diamino-3,5-dicyano-4H-thiopyrans. Treatment of the latter in situ with alkali in DMF, followed by addition of an alkylating agent, led to the formation of 4-alkyl(aryl, hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)-3,6-diamino-5-cyanothieno[2,3-b]- pyridines.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • I. V. Dyachenko
    • 1
  • V. D. Dyachenko
    • 1
  • P. V. Dorovatovskii
    • 2
  • V. N. Khrustalev
    • 2
    • 3
  • V. G. Nenajdenko
    • 4
  1. 1.Taras Shevchenko Lugansk National UniversityLuganskUkraine
  2. 2.National Research Center “Kurchatov Institute,”MoscowRussia
  3. 3.Peoples’ Friendship University of RussiaMoscowRussia
  4. 4.Faculty of ChemistryMoscow State UniversityMoscowRussia

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