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Russian Journal of Organic Chemistry

, Volume 54, Issue 6, pp 878–885 | Cite as

Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines

  • Yu. A. MartinovichEmail author
  • S. M. Ramsh
  • F. Hamoud
  • V. S. Fundamenskii
  • V. V. Gurzhii
  • V. I. Zakharov
  • E. S. Khrabrova
Article
  • 30 Downloads

Abstract

Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N-(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N,N′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea with piperidine and formaldehyde, only symmetrical N,N′-bis(piperidin-1-ylmethyl)thiourea was isolated, regardless of the reactant ratio.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Yu. A. Martinovich
    • 1
    Email author
  • S. M. Ramsh
    • 1
  • F. Hamoud
    • 1
  • V. S. Fundamenskii
    • 1
  • V. V. Gurzhii
    • 2
  • V. I. Zakharov
    • 3
  • E. S. Khrabrova
    • 1
  1. 1.St. Petersburg State Institute of TechnologySt. PetersburgRussia
  2. 2.St. Petersburg State UniversitySt. PetersburgRussia
  3. 3.Research Institute of Hygiene, Occupational Pathology, and Human EcologyKuz’molovskii, Leningrad oblastRussia

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