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Russian Journal of Organic Chemistry

, Volume 53, Issue 3, pp 428–432 | Cite as

Synthesis of new 4-amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol derivatives

  • A. S. AvakyanEmail author
  • S. O. Vartanyan
  • A. B. Sargsyan
Article
  • 59 Downloads

Abstract

Acylation and cyclization reactions of 4-amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol were studied. Acylation of the title compound with substituted benzoyl chlorides gave the corresponding amides, whereas its reactions with substituted benzoic acids in the presence of POCl3 were accompanied by cyclization with formation of triazolothiadiazoles containing a 1,4-benzodioxane substituent. 4-Amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol reacted with substituted benzaldehydes to afford the corresponding Schiff bases, and its alkylation with chloroacetic acid in ethanol in the presence of sodium acetate gave S-ethoxycarbonylmethyl derivative.

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • A. S. Avakyan
    • 1
    Email author
  • S. O. Vartanyan
    • 1
  • A. B. Sargsyan
    • 1
  1. 1.Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia

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