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Russian Journal of Organic Chemistry

, Volume 50, Issue 4, pp 464–468 | Cite as

Synthesis of 1,3-diketones from 3-(4-R-phenyl)propionic acids

  • D. K. Kim
  • E. A. Shokova
  • V. A. Tafeenko
  • V. V. KovalevEmail author
Article

Abstract

Self-acylation of 3-(4-R-phenyl)propionic acids (R = H, Br, 1-adamantyl) in trifluoroacetic anhydride catalyzed by trifluoromethanesulfonic acid provides a simple and efficient synthesis of 1,3-diketones. Indan-1-ones formed in the first step undergo acylation to give the corresponding 2-(3-phenyl-1-oxopropyl) indan-1-ones as the major products. One-pot synthesis of polysubstituted pyrazoles directly from 3-(4-R-phenyl)propionic acids is described.

Keywords

Pyrazole Propionic Acid Enol Hydrazine Hydrate Methanesulfonic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • D. K. Kim
    • 1
  • E. A. Shokova
    • 1
  • V. A. Tafeenko
    • 1
  • V. V. Kovalev
    • 1
    Email author
  1. 1.Faculty of ChemistryMoscow State UniversityMoscowRussia

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