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Russian Journal of Applied Chemistry

, Volume 89, Issue 7, pp 1126–1131 | Cite as

Preparation of new cefazolin-containing films based on chitosan and carboxyarabinogalactan

  • L. A. Badykova
  • R. Kh. Mudarisova
  • I. M. Borisov
  • M. S. Gurina
Macromolecular Compounds and Polymeric Materials

Abstract

Preparation of a polyelectrolyte complex of chitosan with the oxidized form of Siberian larch arabinogalactan at the component ratio from 0.05: 1 to 1: 1 was studied by spectrometry and laser scattering. Water-insoluble films based on this complex were prepared. These films were used as a matrix for drug immobilization. The possibility of controlling the rate and degree of the drug release from the film by variation of the polysaccharide ratio, modification of the polymer film with a sodium dodecyl sulfate solution, or heat treatment was demonstrated with cefazolin antibiotic as example. The films obtained exhibit high bactericidal activity.

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • L. A. Badykova
    • 1
  • R. Kh. Mudarisova
    • 1
  • I. M. Borisov
    • 2
  • M. S. Gurina
    • 1
  1. 1.Ufa Institute of Chemistry, Russian Academy of SciencesUfa, BashkortostanRussia
  2. 2.Akmulla Bashkir State Pedagogical UniversityUfa, BashkortostanRussia

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