Advertisement

Russian Journal of Applied Chemistry

, Volume 88, Issue 1, pp 72–81 | Cite as

Determination of the toxicity of herb preparations of the traditional Chinese medicine with a multisensor system

  • I. S. Yaroshenko
  • D. O. Kirsanov
  • P. Wang
  • D. Ha
  • H. Wan
  • J. He
  • Yu. G. Vlasov
  • A. V. Legin
Physicochemical Studies of Systems and Processes

Abstract

Preparations based on medicinal herbs used in the traditional Chinese medicine to cure and make a prophylactic treatment of a wide variety of diseases wee studied. The goal of the study was to assess the capacity of a potentiometric multisensor system of the electronic-tongue type in an instrumental evaluation of the toxicity of samples being analyzed. The toxicity of herb preparations was evaluated by the cell index calculated from results of an analysis of these preparations by biosensors. A procedure for measurement of samples with the multisensor system was developed. Mathematical models relating the values obtained to reference data were constructed. The parameters of these models suggest that the potentiometric multisensor system can prognosticate the toxicity of samples under study with a relative error not exceeding 11%.

Keywords

Traditional Chinese Medicine Principal Component Regression Cell Index Herb Preparation Parthenolide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Deng, C., Liu, N., Gao, M., et al., J. Chromatogr. A, 2007, vol. 1153, pp. 90–96.CrossRefGoogle Scholar
  2. 2.
    Hai, H., J. Cambridge Studies, 2009, vol. 4, no. 3, pp. 10–36.Google Scholar
  3. 3.
    Jin Sin Jun, Kitaiskaya narodnaya meditsina (Chinese Folk Medicine), Vogralik, V.G., Ed., Moscow: Znanie, 1959, 2nd ed.Google Scholar
  4. 4.
    Witkoppen, J.S., Complem. Therapies in Med., 2003, vol. 11(2), pp. 118–122.CrossRefGoogle Scholar
  5. 5.
    Alves, R.R.N. and Rosa, I.M.L., J. Ethnobiol. Ethnomed., 2007, vol. 3, pp. 14–18.CrossRefGoogle Scholar
  6. 6.
    Sutherland, I.A. and Fisher, D., J. Chromatogr. A, 2009, vol. 1216, pp. 740–753.CrossRefGoogle Scholar
  7. 7.
    Drasar, P. and Moravcova, J., J. Chromatogr. B, 2004, vol. 812, pp. 3–21.CrossRefGoogle Scholar
  8. 8.
    Marchand, E., Atemnkeng, M.A., and Vanermen, S., Biomed. Chromatogr., 2008, vol. 22, pp. 454–459.CrossRefGoogle Scholar
  9. 9.
    Zarzycki, P.K., J. Chromatogr. A, 2008, vol. 1187, pp. 250–259.CrossRefGoogle Scholar
  10. 10.
    Tate, P.A. and Dorsey, J.G., J. Chromatogr. A, 2006, vol. 1103, pp. 150–157.CrossRefGoogle Scholar
  11. 11.
    Razmovski-Naumovski, V., Tongkao, W., Kimble, B., et al., Mod. TCM Mater. Med., 2010, vol. 12(1), pp. 99–106.Google Scholar
  12. 12.
    Jiang, Y., David, B., Tu, P., et al., Anal. Chim. Acta, 2010, vol. 657, pp. 9–18.CrossRefGoogle Scholar
  13. 13.
    Kwon, H.J., Jeong, J.S., and Lee, Y.M., J. Chromatogr. A, 2008, vol. 1185, pp. 251–257.CrossRefGoogle Scholar
  14. 14.
    Gotti, R., J. Pharm. Biomed. Anal., 2011, vol. 55, pp. 775–801.CrossRefGoogle Scholar
  15. 15.
    Jiang, T.-F., Lu, Z.-H., and Wang, Y.-H., J. Anal. Chem., 2007, vol. 62, pp. 85–89.CrossRefGoogle Scholar
  16. 16.
    Hurtado-Fern∂ndez, E., Gymez-Romero, M., Carrasco-Pancorbo, A., et al., J. Pharm. Biomed. Anal., 2010, vol. 53, pp. 1130–1160CrossRefGoogle Scholar
  17. 17.
    Kataoka, M., Tokuyama, E., Miyanaga, Y., et al., Int. J. Pharm., 2008, vol. 351, pp. 36–44.CrossRefGoogle Scholar
  18. 18.
    Liu, R., Zhang, X., Zhang, L., et al., Experim. Therap. Med., 2014, vol. 7, pp. 1696–1702.Google Scholar
  19. 19.
    Wang, Y., Feng, Y., Wu, Y., et al., Fitoterpia, 2013, vol. 86, pp. 137–143.CrossRefGoogle Scholar
  20. 20.
    Du, R., Wang, Y., Wu, F., et al., China J. Chinese Materia Medica, 2013, vol. 38(2), pp. 154–160.Google Scholar
  21. 21.
    Guideline for Good Clinical Practice, Int. Conf., Harmon. 2000.Google Scholar
  22. 22.
    Rukovodstvo po ekspertize lekarstvennykh sredstv v 2kh tomakh (Guidelines for Expertise of Medicinal Preparations in 2 vols.), Mironov, A.N., Ed., Moscow: Grif i K, 2013.Google Scholar
  23. 23.
    Gus’kova, T.A., Syubaev, R.D., Nemkova, I.N., et al., Biomeditsina, 2010, vol. 1, no. 5, pp. 74–76.Google Scholar
  24. 24.
    Corcoran, C.A. and Rechnitz, G.A., Trends in Biotechnol., 1985, vol. 3, no. 4, pp. 92–96.CrossRefGoogle Scholar
  25. 25.
    Wang, T., Hu, N., Cao, J., et al., Biosens. Bioelectr., 2013, vol. 49, pp. 9–13.CrossRefGoogle Scholar
  26. 26.
    Kim, E., Chen, Y., Huang, J., et al., J. Ethnopharm., 2013, vol. 146, pp. 40–61.CrossRefGoogle Scholar
  27. 27.
    Su, K., Zhou, J., Zou, L., et al., Sens. Actuat. A, 2014, vol. 220, pp. 144–152.CrossRefGoogle Scholar
  28. 28.
    Hu, N., Ha, D., Wu, C., et al., Sens. Actuat. A, 2012, vol. 187, pp. 50–56.CrossRefGoogle Scholar
  29. 29.
    Goodarzi, M., Funar-Timofei, S., and Heyden, Y.V., Trends in Analyt. Chem., 2012, vol. 42, pp. 49–63.CrossRefGoogle Scholar
  30. 30.
    Vlasov, Yu.G., Legin, A.V., and Rudnitskaya, A.M., Rus. Chem. Rev., 2006, vol. 75, no. 2, pp. 125–132.CrossRefGoogle Scholar
  31. 31.
    Kirsanov, D., Zadorozhnaya, O., Krasheninnikov, A., et al., Sens. Actuat. B, 2013, vol. 179, pp. 282–286.CrossRefGoogle Scholar
  32. 32.
    Wang, T., Hu, N., Cao, J., et al., Biosens. Bioelectron., 2013, vol. 49, pp. 9–13.CrossRefGoogle Scholar
  33. 33.
    Rodionova, O.E., Khemometrika v analiticheskoi khimii (Chemometrics n Analytical Chemistry), Moscow: Inst. Khim. Fiz., Ros. Akad. Nauk, 2006.Google Scholar
  34. 34.
    Esbensen, K., Multivariate Analysis — in Practice, Norway: Elborg University, Esbjerg: CAMO Process AS, 2001, 5th ed.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • I. S. Yaroshenko
    • 1
    • 2
  • D. O. Kirsanov
    • 1
    • 2
  • P. Wang
    • 3
  • D. Ha
    • 3
  • H. Wan
    • 4
  • J. He
    • 5
  • Yu. G. Vlasov
    • 1
  • A. V. Legin
    • 1
    • 2
  1. 1.Institute of ChemistrySt. Petersburg State UniversityPetrodvorets, St. PetersburgRussia
  2. 2.Laboratory of Artificial Sensor SystemsITMO UniversitySt. PetersburgRussia
  3. 3.Chair of Biomedical EngineeringZhejiang UniversityHangzhouChina
  4. 4.Bioengineering CollegeZhejiang Chinese Medical UniversityHangzhouChina
  5. 5.Pharmaceutical CollegeZhejiang Chinese Medical UniversityHangzhouChina

Personalised recommendations