Russian Journal of Applied Chemistry

, Volume 88, Issue 1, pp 72–81 | Cite as

Determination of the toxicity of herb preparations of the traditional Chinese medicine with a multisensor system

  • I. S. Yaroshenko
  • D. O. Kirsanov
  • P. Wang
  • D. Ha
  • H. Wan
  • J. He
  • Yu. G. Vlasov
  • A. V. Legin
Physicochemical Studies of Systems and Processes


Preparations based on medicinal herbs used in the traditional Chinese medicine to cure and make a prophylactic treatment of a wide variety of diseases wee studied. The goal of the study was to assess the capacity of a potentiometric multisensor system of the electronic-tongue type in an instrumental evaluation of the toxicity of samples being analyzed. The toxicity of herb preparations was evaluated by the cell index calculated from results of an analysis of these preparations by biosensors. A procedure for measurement of samples with the multisensor system was developed. Mathematical models relating the values obtained to reference data were constructed. The parameters of these models suggest that the potentiometric multisensor system can prognosticate the toxicity of samples under study with a relative error not exceeding 11%.


Traditional Chinese Medicine Principal Component Regression Cell Index Herb Preparation Parthenolide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • I. S. Yaroshenko
    • 1
    • 2
  • D. O. Kirsanov
    • 1
    • 2
  • P. Wang
    • 3
  • D. Ha
    • 3
  • H. Wan
    • 4
  • J. He
    • 5
  • Yu. G. Vlasov
    • 1
  • A. V. Legin
    • 1
    • 2
  1. 1.Institute of ChemistrySt. Petersburg State UniversityPetrodvorets, St. PetersburgRussia
  2. 2.Laboratory of Artificial Sensor SystemsITMO UniversitySt. PetersburgRussia
  3. 3.Chair of Biomedical EngineeringZhejiang UniversityHangzhouChina
  4. 4.Bioengineering CollegeZhejiang Chinese Medical UniversityHangzhouChina
  5. 5.Pharmaceutical CollegeZhejiang Chinese Medical UniversityHangzhouChina

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