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Russian Journal of General Chemistry

, Volume 89, Issue 10, pp 2115–2120 | Cite as

Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents

  • B. V. Durga Rao
  • R. Sreenivasulu
  • M. V. Basaveswara RaoEmail author
Article
  • 11 Downloads

Abstract

A series of isoxazole-thiadiazole linked carbazole derivatives 12a12j are synthesized and their chemical structures confirmed by 1H and 13C NMR and mass spectra. The products are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a reference drug. The accumulated data indicate that most of the compounds demonstrate anticancer activity higher than etoposide.

Keywords

ellipticine cefozopram carbazole 1,2,4-thiadiazole anticancer activity 

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Notes

Conflict of Interest

No conflict of interest was declared by the authors.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • B. V. Durga Rao
    • 1
  • R. Sreenivasulu
    • 2
  • M. V. Basaveswara Rao
    • 1
    Email author
  1. 1.Department of ChemistryKrishna UniversityMachilipatnamIndia
  2. 2.Department of Chemistry, University College of Engineering (Autonomous)Jawaharlal Nehru Technological UniversityKakinadaIndia

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