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Russian Journal of General Chemistry

, Volume 89, Issue 10, pp 2044–2051 | Cite as

Synthesis, Structure, and Biological Activity of Cinnamoyl-Containing Cytisine and Anabasine Alkaloids Derivatives

  • O. A. NurkenovEmail author
  • Zh. S. Nurmaganbetov
  • T. M. Seilkhanov
  • S. D. Fazylov
  • Zh. B. Satpayeva
  • K. M. Turdybekov
  • S. A. Talipov
  • R. B. Seydakhmetova
Article
  • 9 Downloads

Abstract

The reactions of the cytisine and anabasine alkaloids with cinnamic acid chloride have been studied, and hydrazinolysis of the resulting N-cinnamoylcytisine and N-cinnamoylanabazine has been carried out. The reaction of cinnamoyl isothiocyanate with alkaloids has afforded the corresponding thiourea derivatives. Antimicrobial and cytotoxic activity of cinnamoyl-containing derivatives of these alkaloids has been evaluated.

Keywords

cytisine anabasine N-cinnamoylcytisine N-cinnamoylanabasine cinnamoyl chloride 

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Notes

Funding

This study was financially supported by the Committee for Science, Ministry of Education and Science of Kazakhstan (PTsF no. BR05236438-OT-18).

Conflict of Interest

No conflict of interest was declared by the authors.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • O. A. Nurkenov
    • 1
    Email author
  • Zh. S. Nurmaganbetov
    • 1
    • 2
  • T. M. Seilkhanov
    • 3
  • S. D. Fazylov
    • 1
  • Zh. B. Satpayeva
    • 1
  • K. M. Turdybekov
    • 4
  • S. A. Talipov
    • 5
  • R. B. Seydakhmetova
    • 6
  1. 1.Institute of Organic Synthesis and Coal Chemistry of the Republic of KazakhstanKaragandaKazakhstan
  2. 2.Karaganda State Medical UniversityKaragandaKazakhstan
  3. 3.Sh. Ualikhanov Kokshetau State UniversityKokshetauKazakhstan
  4. 4.E.A. Buketov Karaganda State UniversityKaragandaKazakhstan
  5. 5.A.S. Sadykov Institute of Bioorganic ChemistryAcademy of Sciences of the Republic of UzbekistanTashkentUzbekistan
  6. 6.International Research and Production Holding “Phytochemistry”KaragandaKazakhstan

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