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Russian Journal of General Chemistry

, Volume 89, Issue 10, pp 2010–2017 | Cite as

Synthesis and Biological Activity of New 2-{[6-Methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl]oxy}acetohydrazide Derivatives

  • V. A. Pivazyan
  • E. A. Ghazaryan
  • Zh. A. Azaryan
  • A. P. YengoyanEmail author
Article
  • 10 Downloads

Abstract

The reaction of 6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4(3H)-one with methyl chloroacetate, followed by hydrazinolysis, gave 2-{[6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl]oxy}acetohydrazide, and the latter was used to obtain a series of new derivatives, including those containing a 1,2,4-triazole, 1,3,4-oxadiazole, or furan ring in addition to the pyrimidine fragment. Preliminary biological screening of the synthesized compounds revealed a pronounced plant growth stimulating effect at a level of 65–87% relative to heteroauxin.

Keywords

2-{[6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl]oxy}acetohydrazide 5-{[(pyrimidin-4-yl)oxy]-methyl}-4H-1,2,4-triazole-3-thiol 5-{[(pyrimidin-4-yl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione plant growth stimlants 

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Conflict of Interest

No conflict of interest was declared by the authors.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • V. A. Pivazyan
    • 1
  • E. A. Ghazaryan
    • 1
  • Zh. A. Azaryan
    • 2
  • A. P. Yengoyan
    • 1
    • 2
    Email author
  1. 1.Pesticide Synthesis and Plant Protection Research CenterNational Agrarian University of ArmeniaYerevanArmenia
  2. 2.Department of General and Pharmaceutical ChemistryRussian-Armenian UniversityYerevanArmenia

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